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Retired NBME 16 Answers

nbme16/Block 4/Question#26 (reveal difficulty score)
A 42-year-old woman undergoes biopsy of ...
High-grade, low-stage neoplasm ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—bingcentipede(359)
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Grade refers to the differentiation, whereas stage refers to the TNM decriptions

This is high-grade because of the "poorly demarcated... cells growing in sheets" wit a high N:C ratio. Means it's got low differentiation.

This is low-stage because there is NO METASTASIS. Even though there is invasion (and thus, a cancer), M for the TNM is most important.

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the_enigma28  Excellent explanation. For additional info, look up at Page 220, FA 2020. +
melanoma  Uw Q1759 +



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