need help with your account or subscription? click here to email us (or see the contact page)
join telegramNEW! discord
jump to exam page:
search for anything ⋅ score predictor (โ€œpredict me!โ€)

Retired NBME 16 Answers

nbme16/Block 4/Question#34 (reveal difficulty score)
A 43-year-old woman comes to the physician ...
Degeneration of motoneurons of the lumbar cord ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags:

 Login (or register) to see more


 +3  upvote downvote
submitted by โˆ—aoa05(34)
get full access to all contentpick a username

Weakness with decreased muscle bulk implies problems that include the lower motor neuron system. Decreased DTRs implies a disrupted reflex loop but the absence of sensory loss implies that it is on the motor side of the reflex loop. Of the available choices, B is the best fit. "A" is arguably true because a strictly motor polyneuropathy (such as in lead poisoning) could account for the findings, but a 3-month course could hardly be called "acute."

get full access to all contentpick a username
itsalwayslupus  I was able to deduce the right answer, but what is the specific reason against "demyelination of the corticospinal pathways"? just out of curiousity +1
lsp1992  I believe it's because damage to the corticospinal tract would be considered UMN damage, while degeneration of motorneurons is LMN damage. LMN damage causes decreased reflexes. UMN disease would cause hyperreflexia....I think. That's how I reasoned through it at least +20
nbmeanswersownersucks  I also think you can rule out peripheral neuropathy because typically that includes both motor and sensory +4
saqeer  yes but is not Achilles an S1 reflex (sacral cord) ? how does the degeneration in lumbar cord affects it ? i rule it out first thing because of this :S +
meryen13  i think she just had a dics herniation. there can be problem with temperature and sensation in some case but those are usually very severe herniations. not sure tho... but it can on your differentials. +
djeffs1  I assumed that "motoneurons of the lumbar chord" means upper and not peripheral +
sexymexican888  Is this ALS? +1
dawgtor  @saqeer , i had the exact same question. Can someone please help me out with this? +
ali_hassan  well pateller reflex is also diminished and it's an L3/L4 reflex so I wouldn't have ruled it out that quickly. I agree with @meryen13 it was probably a disc herniation that affected L and S of the spinal cord +
chaosawaits  How would "loss of afferent Ia axons innervating muscle spindles" present? That's the other I was torn between. +2
an1  @ sexymexican888 seems like it, but ALS is LMNL + UMNL. this patient only has LMNL. UMNL is a neuron issue before decoration, whereas LMNL will be affecting regions after the decussate (as in when they've reached the spinal cord) +



Must-See Comments from nbme16

bingcentipede on Cerebral edema
zincy7 on Gastrin
cassdawg on Kidney
medninja on Lysosomes
cassdawg on Sildenafil
cassdawg on Feces-contaminated soil
cassdawg on Presence of an internal ribosome entry site
cassdawg on Peutz-Jeghers
hungrybox on Induction of cytochrome P450 enzymes that ...
andro on Antagonizes VLDL-cholesterol secretion
bingcentipede on Decreased function of Na+โ€“K+ ATPase
bingcentipede on Glyceraldehyde-3-phosphate dehydrogenase
cassdawg on 46,XXY
bingcentipede on Grade 4/6, holosystolic murmur heard best ...

search for anything NEW!