NBME 16 Stimulation of hepatic glucose production (NBME Answers)

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NBME 16 Answers

nbme16/Block 1/Question#34 (reveal difficulty score)
A 39-year-old woman with type 1 diabetes ...
Stimulation of hepatic glucose production 🔍 / 📺 / 🌳 / 📖
tags: biochem pharm

+4 upvote downvote
submitted by ∗torticollis(4)

If she ain't taking beta blocker... why this patient does not present any symptomatology before during hypoglycemic episode?

+3 upvote downvote
submitted by ∗bingcentipede(355)

T1DM, she's getting hypoglycemia. The most appropriate medication is glucagon, which would stimulate hepatic (not skeletal muscle) glucose production

neurotic999 isn't there something about the glucagon response being absent in diabetics. i'm not sure in which question bank i came across this point, but i have it written in my FA with no further explanation (my bad). anyone else with the same doubt? https://care.diabetesjournals.org/content/35/8/1757 https://pubmed.ncbi.nlm.nih.gov/4581053/ +

fatboyslim ^Yes, because in T1DM there is not only destruction of the pancreatic beta cells (make insulin), but also alpha cells (make glucagon) +

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