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Retired NBME 16 Answers

nbme16/Block 1/Question#48 (reveal difficulty score)
A newborn female is diagnosed with ...
Thyroxine (T4) ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +3  upvote downvote
submitted by โˆ—motherhen(69)
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In other words, what is the active product of the thyroid gland that is needed for normal development? Only thyroxine, iodine and thyroglobulin are in the thyroid gland. Of these, thyroxine is the active hormone produced that would affect development.

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cheesetouch  *refuting thyroglobulin * Wikipedia: Thyroglobulin (Tg) acts as a substrate for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), as well as the storage of the inactive forms of thyroid hormone and iodine within the follicular lumen of a thyroid follicle +
nikhilredd  in pregnancy always keep an eye open for the harmones that can cross the placenta such as the thyroid hormones( not a steroid),cathecolamines( amino acid derivatives),corticosteroids and steroid hormones +



 -7  upvote downvote
submitted by โˆ—bingcentipede(359)
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Sounds like a negative feedback question. If T4 crosses the placenta, it basically inhibits TSH release. Then the newborn won't be making TSH, so this could be like a transient hypothyroidism

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taylor5479  If it was a negative feedback question, there would still be some measurable thyroid gland tissue in the newborn, it would just be atrophied. It's essentially asking why the baby developed normally with no thyroid of her own, and that's because of the presence of maternal T4, which is no longer available after birth. +1



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