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NBME 18 Answers

nbme18/Block 3/Question#46 (16.3 difficulty score)
45 yo man for annual health maintenance ...
FenofibrateπŸ”
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 +7 
submitted by dorsal_vein(32),
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ayMn densttus ilwl get this oueqstin rwnog beausce fo a irimasl iuqnotes no dworUl. isTh tapnite sah na rytelxeme hgih dregcytiiler eevll nda ahs no ishtoyr of vocrdaicraluas ias.edes stbariFe dholsu be iebsdercrp to repnevt ttpasn.iraeic

lokotriene  Not sure which UW questions you're referring to, but I found a couple that agree/support Fibrates for lowering isolated triglyceride elevation incase anyone wants to reference them for clarity. #11844 & #166 +  
username  Talking about in situations where the patient has cardiovascular event, serum lipid values show OKAY cholesterol levels but increased triglycerides. Q will ask what to add to patient's regiment. In this case, if answer choice throws you fibrates, you'll want to bite, but if patient has cardiovascular disease, you're going to want to go with statins +1  



 +0 
submitted by donttrustmyanswers(58),

According to UpToDate:

At levels below 886 mg/dL (10.0 mmol/L), the risk of pancreatitis appears to be quite small [76-78]; however, it is reasonable to consider drug therapy at levels of 500 mg/dL (5.6 mmol/L) or above in patients with a prior episode of pancreatitis.

Bonus: They say fenofibrate>gemfibrozil always.




 +0 
submitted by feliperamirez(31),
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oAcdncirg ot eht AHA eyevr enaptti twih GT obvea 005 ldshou ceviree esbfatir, even ohhutg stiatns cna asecdere TG l.evsle