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Retired NBME 18 Answers

nbme18/Block 1/Question#2 (reveal difficulty score)
32 yo man, HIV infection comes to the ...
Reverse transcriptase and protease ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—hello(429)
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This patient has been taking HAART therapy and subsequently develops resistance mutations. The therapeutic purpose of HAART therapy is to target reverse transcriptase and protease enzymes. Since the patient is taking HAART therapy and subsequently developed viral resistance, we know the resistance has developed due to mutations in the genes that encode reverse transcriptase and protease.

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cbreland  "High viral load" made me think that the main issue was rev transcriptase inhibitor being messed up. Picked the only answer with that as an option +2
pfebo  Adding to Hello comment, it is a pol gene mutation. +
avatar  whats the treatment for HAART resistance? is it Enfuvirtide +



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