Lose GI defense mechanism -> loss of parietal cells.
ECL cells may hypertrophy to encourage acid secretion because the parietal cells are not responding to their usual signals. Zollinger-Ellison/gastrinoma causes hypertrophy of the gastric mucosa so that is also wrong.
pg32I would also add that I think they are specifically trying to get us to think of pernicious anemia here, where parietal cells are destroyed/lose their fxn. In that case, ECL cells may hypertrophy to encourage acid secretion because the parietal cells are not responding to their usual signals. All the other answer choices are quite clearly incorrect, and Zollinger-Ellison is a gastrinoma, which causes hypertrophy of the gastric mucosa so that is also wrong. +12
epiglotittiesAlso, supporting what @pg32 said, autoimmune gastritis preferentially affects the body/fundus of the stomach (same areas affected in the experimental animal).+
submitted by โcheesetouch(249)
Lose GI defense mechanism -> loss of parietal cells. ECL cells may hypertrophy to encourage acid secretion because the parietal cells are not responding to their usual signals. Zollinger-Ellison/gastrinoma causes hypertrophy of the gastric mucosa so that is also wrong.