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NBME 21 Answers

nbme21/Block 1/Question#9

A 53-year-old woman who underwent an operation for ...

Breast: antagonist; Uterus: partial agonist

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submitted by pparalpha(23),

Tamoxifen

Mechanism: selective estrogen receptor modulator (SERM) that acts as an antagonist on the estrogen receptors of the breast and acts as an partial agonist on estrogen receptors in bone and uterus. Therefore, ↑ risk of endometrial cancer and ↑ Risk of uterine sarcoma

Uses: ER or PR positive tumors (breast)