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NBME 21 Answers

nbme21/Block 1/Question#36 (62.4 difficulty score)
A 51-year-old woman comes to the physician ...
Area labeled 'B' (Parietal cell)πŸ”

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submitted by h0odtime(47),
  • Gastrin released by G Cells pyloric antrum, duodenum, stomach stimulates parietal cells to secrete HCl.
  • Parietal Cells (Fundus + Cardia) epithelial cells that secrete HCl and intrinsic factor. They activate gastric chief cells to secrete digestive enzymes.
  • Gastric Chief Cells (Mucosa): releases pepsinogen and chymosin


  • A Mucous Neck Cell
  • B Nucleus of Parietal Cell
  • C Nucleus of Chief Cell
  • D Nucleus of Endothelial Cell
  • E Nucleus of Fibroblast

Credit to Histo_Man/reddit

lovebug  THX for kindful Lables! +1  

submitted by mcl(598),
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ihsT maieg is vyre .ufplhel

seagull Another histology slide with labels +2  
masonkingcobra  I like to think that the parietal cells look like "fried eggs" classically +  

submitted by seagull(1554),
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toAnher ltoiyosgh ldsei iwht slbale a few ocnesds gao

enbeemee  what are the other labeled structures? i can discern the parietal and chief cells, but not really the others... +1  
hyperfukus  yea wth is A +1  

submitted by enbeemee(13),
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awht rea the thoer aeedbll utrsetusc?r i cna esnrdic het ilpratae dna ceihf cls,el tbu ont eht teor.s..h

hyperfukus  what is A? +  
et-tu-bromocriptine  According to this source, they're mucous neck cells (secrete acidic fluid containing mucin); compare this with mucus produced by surface mucous cells, which is alkaline. +2  
hyperfukus  i gosh i see now! thanks so much :) so if it's Pink=Parietal but not granules got it thank you :) +