Toll like receptors are pattern recognition receptors (on innate immunity cells like macrophages) that recognize pathogen associated molecular patterns (PAMPs) and lead to activation of NF-kB. One example of a PAMP is LPS (gram negative bacteria). This leads to secretion of IL-1, IL-6 (cause fever), TNF-a (causes fever and hypotension), Nitric Oxide (causes hypotension).
Complement activation itself leads to hypotension via C3a, as well.
All this can be found on page 133 on FA, as @meningitis pointed out, and page 99 of FA 2019.
submitted by โmeningitis(644)
LPS found in outer membrane of gram โ bacteria (both cocci and rods). Composed of O antigen + core polysaccharide + lipid A (the toxic component).
Activates Macrophages and induces TNFalpha release -> Hypotension and fever.
Pg 133 Endotoxin.