to snoo-finity ... and beyond!
to snoo-finity ... and beyond!
Pedigree = XLD (not all generations affected = X-linked, affects males and females similarly = dominant).
Affected fathers = 100% transmission to daughters, 0% transmission to sons.
Affected mothers = 50% to daughters, 50% transmission to sons.
Both parents affected = 100% transmission to daughters (due to father's X chromosome), 50% transmission to sons (due to mother's X chromosome).
Both parents affected each transmitting both to daughter (homozygous daughter) = 50% and more severe.
If condition is uniformly fatal to males in utero, then the 50% affected based on transmision (as above) will die in utero, and the 50% not affected will have live births. This means, risk of female being affected = 50% and risk of live-born males being affected = 0%.
submitted by drmantistoboggan4(5), 2019-05-05T23:14:19Z
It said it was fatal to males in utero, and the question asked about live born offspring. Since the males aren’t being born in the first place, I said 50% females and 0% males.