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NBME 21 Answers

nbme21/Block 2/Question#23 (reveal difficulty score)
A 4-year-old boy with chronic granulomatous ...
Macrophages producing interleukin-1 (IL-1) 🔍 / 📺 / 🌳
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 +11 
submitted by lsmarshall(452),
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ehT toms decirt ,tahp dan ostm ilkyel thap, rfo barste earncc ot aeimtatsezs to het rrevateb rae teh tontrasciel sienv. Tshi wsa on na aeleirr NEMB stte sa l.ewl tBrsae nccaer lwil caseu iexmd, cytli adn casbtli esilnso ncoe in .oben

nO an latdnreeau t;eno I nlalyfi meca up itwh a enedct awy ot eerbermm cltyi .sv atclisb ncsecar ni neo!b

YdnekI dan tdIorYh uasce IlctY

rstpeoat t&;g saetabtl ;gt& btaislc

wTo sbetasr gt;& wot sypet of inselos ;> B etrsa aussec B hot

wTo unsgl &t;g otw etyps of isnelos ee(gnndpdi on type fo unlg an)crce

claselml-l nulg ;gt& lmla"s stl"asb

mnanls-ol lecl &tg; lciyt


 +2 
submitted by trazobone(86),
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I wsa so ieafxtd no hte fcta that ni a TB mrgn,aluoa hasemacgrpo dcupero I12L or pFT,lhaaN otn I1.L oS I teeimdlain C nda dkeccli ,B eevn tho st’i not 4DC oystheypclm ttah erocudp pFNa.aThl uBt het cfat atht amcparhsoge udrpeco 1LI illst tn’did ekma yan n.ssee

I todcnlu’ ndfi ayn aioentpaxln ni stfri dia rfo stih i(t dnotes’ ltle oyu thwa llces eseretc ,)1LI utb aoincrgdc to my onset orfm an imnmou ecreult I lfah apdi eitnoantt ot, 1IL si a ekoticyn fo tanein nmtiiymu tsederec yb octnsmeo,y pa,gemcsharo eillhaeondt elscl, nad haplelieti lslec; os aslaybcli eyvd.ybeor Tshi oseg ni nnnccujtioo wiht vnheetiygr tath AF syas AF(18 .p 180)

makingstrides  Macrophages secrete Il-1,6,8,12 and TNF - alpha. In this scenario, the patient is Il-12 receptor deficient. When macrophages engulf an object, it releases Il-12 to stimulate T-lymphocytes, that in return, release Ifn-gamma, which would convert the macrophage into an epithiliod histiocyte. +2  
abk93  making strides is a baller Thank you +  
abk93  why is this patient il-12 deficient? +  



 +1 
submitted by usmle11a(94),
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NIF y wlil htbinii oerafttnidiiefn fo hT2 llcse nda reeftheor e,a( wb rn))go touaerlygr T dcels) l if het ecsa saw lginakt uoatb irusv

teepot123  fa 19 pg 108 +  



 +1 
submitted by temmy(144),
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INF mgaam estlastimu mgrasaeohpc to codpuer gralusmoan




 +1 
submitted by abk93(3),
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ciiSyeal,fplc wtha is eth prpeosu of 1lI- in stih stqnuoi?e

si it sujt ttah erpsacmoahg aemk ?-1Il

teo'dsn aperap to be levonivd in ugraamnlo rmo.atifon




 +0 
submitted by meryen13(36),
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oenenritfr mgmaa ilwl od a few nsgthi in -tbyo&d;-g 1 vteaitca phmaseragoc to klli! ro ot eomcbe dtihieeolp ttsyciheio to lawl off iif.esnctno -2 ti llwi nrseaeci hte cam clemusloe no eth esufcra fo het lse.cl .3 ti tiisbnih neotaiftrieidfn fo t elcl ot ht2 ellc absceeu 2ht has nait nlmoiaarymft (i-l10 )tsceonrei adn pecnlishoioi atiotivnca nuifncot. 4. laso divtateca het kn lescl ot trtsa !llngiki

bbr  and (just for completeness), promotes Th1 +  
ege  what does "Mac" stand for? "it will increase the mac molecules of the surface of the cells." Thanks! +  
saqeer  mac= membrane attack complex +2  



 +0 
submitted by jatsyuk38(1),
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etosn'd aa-gIFmNm rapeuletug HICMI? icWhh wdluo tecivtaa T yhesoplcymt ot ecroupd o tieIk?scny do gte ywh hacapsorgme si hte ebttre ewrsa,n tbu 'dtndi rdunsntade ahwt I-L1 hda to do with hgt..inny.a




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