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NBME 21 Answers

nbme21/Block 2/Question#45

A 3-year-old boy is brought to the emergency ...

Synthesis of factor X (Stuart factor)

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 +7  upvote downvote
submitted by mcl(132),

Not sure if this is the right way to think about it, but if PT and PTT are both prolonged, this most likely means there is a problem with the common pathway (aka factor X).

temmy  exactly...i just thought the problem has to be where they meet or somewhere similar to both..hence the common pathway 12(PTT Heparin) 7 (PT, Warfarin) 11 9 10 5 2 1 In my head, both sides are looking for the perfect 10 +  

 +0  upvote downvote
submitted by usmle11a(1),

i did this through elimination:

a,c and D intrinsic; ↑PTT only

B) which is actually the PIP2; involved in Gq signaling