NBME 21

nbme21/Block 4/Question#14

A 25-year-old woman has a 3-week history of ...

Autoantibodies against platelet glycoproteins

Login to comment/vote.

 +1  upvote downvote
submitted by cellgamesgojan(3),

The patient suffered from Immune Thrombocytopenia. autoantibodies against the glycoproteins GP2B/3A.

On labs, you’ll see: increase in megakaryocytes; on the question stem they’re described as “rare but large.” Megakaryocytes are not suppressed.


 +1  upvote downvote
submitted by krazyglue5(1),

She has ITP/immune thrombocytopenia, so she has autoantibodies against her platelets, specifically GPIIb/IIIa. She has the large megakaryocytes because her bone marrow is trying to churn out platelets. She’s a woman of child-bearing age with increased bleeding time but no other neurologic abnormalities/renal issues/fever, so think ITP.