NBME 21 IgG plus complement (NBME Answers)

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NBME 21 Answers ↦

nbme21/Block 4/Question#24 (36.2 difficulty score)
A 56-year-old man undergoes a renal ...
IgG plus complement🔍
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+11
submitted by h0odtime(47),

Transplant Rejections (p.119)

Hyperacute - Minutes pre-existing Ab attack new organ Ag + activate complement T2
Acute - Weeks CD8 +/- CD4 bind organ MHC. T4
Chronic - Months/years CD4s can activate macrophages and mediate damage T4, or activate B cells --> Ab --> damage graft. T2 or T4
GVH - Time varies, organ with T-cells grow and reject foreign host. T4

Transplant Types

Autologous Self skin grafts
Allogenic Normal organ transplant
syngeneic graft (isograft) Monozygotic twins
xenograft animal to human heart valves

ABCD Hypersensitivity (p.112 FA2020)

T1 : Anaphylactic & Atopic
T2: (anti)Body-mediated
T3: Complex (Immune)
T4: Delayed Cell Mediated

+4
submitted by hayayah(1076),

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eetHracuyp atnartspln incjrteeo cuocsr inhwit tnuesim dt/ eipteisrgxn- epirneitc etndoasibi atth aetcr to nrood naiteng (etpy II yvyprtsiethsenii antroce)i, teatcavi emco.lmtpen

mcl [Useful figures illustrating transplant rejection](https://www.stomponstep1.com/transplant-rejection-hyperacute-acute-chronic-graft-versus-host/) +

drdoom ^ via @mcl [Useful figures illustrating transplant rejection](https://www.stomponstep1.com/transplant-rejection-hyperacute-acute-chronic-graft-versus-host/ +1

+0
submitted by priapism(6),

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Pre iFrst i:dA ensiobdtia agntias OBA oblod tpesy dnet to be IMg ro gIG, ihchw is hyw het nrseaw si GgI + eecopmmntl adn otn IgA + ltecpmmeon

yotsubato IgA also has no role in any hypersensitivity reaction +2

divya hi. where is this given in first aid? +