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NBME 21 Answers
A 28-year-old woman with chronic renal failure ...
HCTZ and acetazolamide would also deplete potassium, they are just not as strong of diuretics. To be potassium-sparing, it has to have effect at the collecting ducts. Any diuretic that works before the collecting ducts will increase the concentration of sodium going to the collecting ducts and stimulate sodium/potassium exchange at the collecting ducts, potentially leading to decreases in potassium