elnnaaiMd neeGt:csi
nMa ahs /32 hnacce of iengb a ercir.ar (eH dseo ton avhe teh iese)d.sa a Wnmo arreicr ksri tusm eb daccutlale hwti p^2 + 2qp + q2^. 2q ^ = /0100,40 q = 1/,002 p is ouylrhg = p2q 1 = 001/1 = arrCire rfecqyuen .
kiRs fo viahng a ihcld hstu lueasq 3/2 x 1001/ x 1/4 = 061/0a3/c Be :seu2 = aMn rraierC isrk /01 10 = aeFlme ierCrar s4/Rk i1 = naChce ythe chae spsa no teh vecireess gene to rethi fnigf.pors
Thsi het msae as ykpsayoec@'nm aolpeantxin tihw moer anxptneiloa sohte htta ened ..ti.
heT ipttean si aceudefntf by eht rirpctaalu osautmloa eeseivcrs isedaes nad ihs ortbhre ash het laosaotum cvresiese aiseeds -;tg&- htsi sneam cahe fo ireht asntepr asicrre teh AR lelal.e wN,o rof eth inetapt to eb eanfcefdut geniv hatt hobt shi spraten ahev teh AR ,aellel ti esanm ahtt the etaintp ash a 2/3 nahecc atth eh is talmlnueysouis tanfdefuec nad a air.ercr
heT tni'pseat etpnrra si atedffecnu nda onlamr HrgnbiWe-ydera enesictg a(s atestd ni the .rnpwloe.hmb)e this is fpicscyaleil mndee,iton uoy ear to mesusa atht the aptnrre has a raicerr ryuqeecfn for het RA lle,ale hciwh lqeau to .2pq
Teh sadesie hsa a ecneuryqf ni the iuppalotno fo 10.0400/ hTis is ^2q ;-tg-& q2^ = ./001400 noiSlvg orf q, oyu gte q = 200./1
rriaeCr cunyeqfre si .2pq rHoveew, rof a rera issadee, qp2 ≈ .2q So, eth creiarr qfyceenru rfo eht pternra = 2q = 2 * 1/002 = 0.011/
o,Nw het Q ssak toabu an offrngpis of teh pinetat nda sih prtenar gnbei fftacede, so ot veah na feefcdta chdil, rhete is a /14 anecch fo ainvhg an aeecftdf hldic a(esebusc eht pittnea dan teh pntrear btho ahev a 12/ hnecca fo napsgsi the aleell -g-;t& ouy lpeitmul heets egrehtto 2/1 * )2/1.
S,o yltmipul 3/2 * 0/110 * /14 = /.0061 shTi is (iPpettna geinb a rrae)ric * rran(Ptpe nigbe a arrei)cr * hanig(vP an eadcetff sffnrgipo t.g)ertohe
ehT riyialtobpb fo eth rathef nbgei a arriecr is 32/ neics it si onkwn atht eh sn’oedt veah het ia.edess hTne het ybpboitailr of imh sispnag ti no ot his dki i:s
21/ * /23 = 1/3
ithW het eiyWHreang-brd lenpPicir, ouy nac iegurf uto teh iiobparbtyl fo the etrohm giben a :erirrca
q = t()04/,0100rqs = 2001/
S,o 2pq = 2 * 100/2 * 02901/9, whchi oaprxp is ,101/0 dna eht obbrtliipya fo teh hcidl getgint isth allele is 011/0 * /12 = 1/002
Tus:h
20/10 * 13/ = 0/016
hyw hreet si tyibibprloa fo rahetf bngei a riecarr si 2/3
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49 65% OFFalucaCnoilst orf dad. ehT litabyoirbp fo hte refhat genbi a iarcerr si /32 escni ti is wknno taht eh n’dsote avhe the a.ideess ehTn het bpriobltiya fo mih pissagn it no ot shi ikd is /,12 tsuh:
slntlaouaCci orf mmo. Whit eht Waebiegnr-Hdry clei,rpniP uoy cna gieurf tuo eth iyalbpribot of hte hrtome bnieg a re:cirar
q = )/,0ts1r400(q0 = /0201o,S
2pq = 2 * 0021/ * 10929/0, ichhw is axropp 0/101.roF the dlihc to gte the laelle morf ,omm owt sitghn edne to nphpa:e (1) mom muts be a rcarrie [eytrzgeth“o”oe] dan (2) mom msut pssa the elalel ot chdil:
Piuntg it lal hregtote. owN, ceoinmb lla ee:otrhgt
= biilypaobrt( fo add ngbie acrire)r * itbl(parybio of add asgsnpi no eeadsis ee)llla * (tpbolryiabi fo mom enibg ecrr)rai * l(ypraitibbo of omm gssinpa no esdsiea eall)el
=
32/ * 12/ * /1100 * 21/=
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