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Retired NBME Free 120 Answers

free120/Block 3/Question#23 (reveal difficulty score)
In a cohort study of elderly women, the ...
Statistically significant overall increase in risk ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: biostats

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submitted by โˆ—bwdc(697)
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An odds ratio greater than 1 signifies increases odds, risk, likelihood -- whichever you prefer to call it. If the 95% confidence interval range does not include 1, then the difference is statistically significant (though not necessarily clinically meaningful).

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tallerthanmymom  Can someone explain why it is an increase in risk rather than a decrease? Also, relative to what? Do we just assume it is relative to people who do not exercise regularly? +
banana  Uncertain about this, but I think from my memory of the question that the above explanation should say "relative risk" and not odds ratio. The relative risk is the (number women fractured/total exposed)/(number women fractured/total unexposed):: therefore, >1 means that more women got fractured when they exercised. (FA 2020, 258) +1
drpee  Same risk: RR = 1 (theoretical). Lower risk: RR < 1. Greater risk: RR > 1 +4
blah  I got confused by the question because I was bringing in my own biases (i.e. doesn't exercising decrease the risk of fractures in this population of women?). If you simply read the question as what does a RR>1 mean? No doubt you'll get the correct answer. +8
chaosawaits  Same, I got confused based almost solely on my understanding that exercise decreased risk of fractures. Then I mixed up statistically significant with clinically significant. +1
an1  I feel like a smilier q has popped up on an NBME or UW. But yes, RELATIVE RISK is >1 so that increases the chances. Also, it says old women. They're more likely to actually fracture something while working out in reality too +



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