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NBME 16 Answers

nbme16/Block 2/Question#5 (reveal difficulty score)
A 51-year-old man who is a farmer comes to ...
Leukemoid reaction ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: hemeonc repeat

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submitted by โˆ—okokok1(38)
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A way to differentiate between a leukemoid reaction vs CML is that CML has a very low leukocyte alkaline phosphatase (LAP) as a result of low activity in malignant neutrophils, vs benign neutrophilia (leukemoid reaction) in which LAP is ย due to ย leukocyte count with neutrophilia in response to stressors (eg, infections, medications, severe hemorrhage).

Also some helpful hints is that his temperature is raised as well as his leukocyte count. So an infection from his cut.

I think "leukoclastic response" was just there to trip you up. The closest thing I could find to that term online was: Leukocytoclastic vasculitis (LCV), which refers to small blood vessel inflammation.

Leukopenia is LOW leukocyte count.

Leukoplakia is that "white plaque" you see with Bowens disease (squamous cell CA of penis) and can also be seen in vulvar CA.

Leukotrienes deal with your immune system and are synthesized and released on demand from basophils.

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okokok1  *leukemoid reaction will have elevated LAP due to elevated leukocyte count +



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