NBME 18 Colipase (NBME Answers)

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Retired NBME 18 Answers

nbme18/Block 3/Question#48 (reveal difficulty score)
52 yo man, chronic pancreatitis
Colipase 🔍 / 📺 / 🌳 / 📖
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submitted by ∗sugaplum(487)

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Cholesterol ester hydrolase is needed for reverses cholesterol transport, not pancreatic enzymes.
- I missed this
https://www.ncbi.nlm.nih.gov/pubmed/20947831

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+6 upvote downvote
submitted by ∗breis(56)

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Colipase is a protein that functions as a cofactor for pancreatic lipase, with which it forms a stoichiometric complex. It also binds to the bile-salt covered triacylglycerol interface thus allowing the enzyme to anchor itself to the water-lipid interface.

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cbreland Lipase (active) and procolipase (inactive) are both secreted by the pancreas. Lipase is inactivated by bile salts in the intestines. Colipase (once activated by trypsin) is able prevent the interaction of bile salts and lipase. End result being that lipase is doesn't have to worry about bile salts if colipase is around +4

s039p811 To add onto this, I had picked Phospholipase A2, but that's used for phospholipid hydrolysis and not triglyceride hydrolysis specifically. +

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