need help with your account or subscription? click here to email us (or see the contact page)
join telegramNEW! discord
jump to exam page:
search for anything ⋅ score predictor (โ€œpredict me!โ€)

Retired NBME 18 Answers

nbme18/Block 2/Question#1 (reveal difficulty score)
A 25-year old woman comes to the physician ...
3 to 8 weeks ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: repro

 Login (or register) to see more


 +3  upvote downvote
submitted by โˆ—cheesetouch(250)
get full access to all contentpick a username

Teratogens are most susceptible to give damage in 3-8th weeks (embryonic period - organogenesis) of pregnancy. FA p 596 (2018); teratogens section

get full access to all contentpick a username
cbreland  as @azibird stated below, the neural tube starts to form at the 3rd week and completely forms by the 4th week. Valproic acid can cause NTD, affecting their formation in weeks 3-4. +4



 +2  upvote downvote
submitted by โˆ—azibird(279)
get full access to all contentpick a username

FA2020 p491 Neural tube defects Neuropores fail to fuse (4th week)

The 4th week falls in the range of 3 to 8, but such a wide range threw me off and I picked 0 to 2 anyway.

get full access to all contentpick a username
overa  the first 2 weeks are "all or none". so usually if the fetus is exposed to teratogens here, it will either terminate the pregnancy or the baby will be unaffected. +3



Must-See Comments from nbme18

feliperamirez on He is medically qualified to drive
anechakfspb on Tubular atrophy
aneurysmclip on Endothelial nitric oxide synthase production
azibird on 24,25-Dihydroxycholecalciferol
famylife on Increased transcription of HMG-CoA reductase
match95 on Plasmid loss
apurva on Antineoplastic
cbreland on Basement Membranes
match95 on Proximal tubule: isotonic; Macula densa: ...
sugaplum on Abnormal migration of endoderm from the ...
amirmullick3 on Myelofibrosis
merpaperple on Primary spermatocyte
wishmewell on Alpha-synuclein
namira on Greening reaction on blood agar

search for anything NEW!