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NBME 18 Answers

nbme18/Block 2/Question#1 (reveal difficulty score)
A 25-year old woman comes to the physician ...
3 to 8 weeks ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: repro

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 +3  upvote downvote
submitted by โˆ—cheesetouch(249)
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Teratogens are most susceptible to give damage in 3-8th weeks (embryonic period - organogenesis) of pregnancy. FA p 596 (2018); teratogens section

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cbreland  as @azibird stated below, the neural tube starts to form at the 3rd week and completely forms by the 4th week. Valproic acid can cause NTD, affecting their formation in weeks 3-4. +4



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submitted by โˆ—azibird(279)
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FA2020 p491 Neural tube defects Neuropores fail to fuse (4th week)

The 4th week falls in the range of 3 to 8, but such a wide range threw me off and I picked 0 to 2 anyway.

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overa  the first 2 weeks are "all or none". so usually if the fetus is exposed to teratogens here, it will either terminate the pregnancy or the baby will be unaffected. +3



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