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NBME 18 Answers

nbme18/Block 2/Question#1 (7.7 difficulty score)
A 25-year old woman comes to the physician ...
3 to 8 weeksπŸ”,πŸ“Ί
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 +3 
submitted by cheesetouch(191),

Teratogens are most susceptible to give damage in 3-8th weeks (embryonic period - organogenesis) of pregnancy. FA p 596 (2018); teratogens section

cbreland  as @azibird stated below, the neural tube starts to form at the 3rd week and completely forms by the 4th week. Valproic acid can cause NTD, affecting their formation in weeks 3-4. +2  



 +2 
submitted by azibird(197),

FA2020 p491 Neural tube defects Neuropores fail to fuse (4th week)

The 4th week falls in the range of 3 to 8, but such a wide range threw me off and I picked 0 to 2 anyway.

overa  the first 2 weeks are "all or none". so usually if the fetus is exposed to teratogens here, it will either terminate the pregnancy or the baby will be unaffected. +3