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Retired NBME 18 Answers

nbme18/Block 2/Question#21 (reveal difficulty score)
66 yo woman, 2 days of fever, flank pain, ...
Calcium carbonate ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +5  upvote downvote
submitted by โˆ—krewfoo99(115)
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Calcium Carbonate is an antacid which can chelate and decrease effectiveness of other drugs such as tetracyclines and fluroquinolones

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 +3  upvote downvote
submitted by madmoroccan(3)
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divalent cations interfere with the absorption (adsorbtion?) of Ciprofloxacin.

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redvelvet  divalent cations interfere with the absorption of tetracyclines, not fluoroquinolones. anti-acids interfere with the absorption of fluoroquinolones. (like in this q, it's ca carbonate) +3
keyseph  According to SketchyPharm, divalent cations also interfere with the absorption of fluoroquinolones +14
nbmeanswersownersucks  Calcium carbonate is an antacid but it has Calcium in it....which is a divalent cation +4



 +2  upvote downvote
submitted by โˆ—an1(114)
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Common Chelators:

  • Iron
  • Calcium
  • Mg
  • Aluminium

Commonly Chelated Drugs:

  • Tetracyclines
  • Fluoroquinolones
  • Levothyroxine

These create insoluble complexes and are inhibited from being absorbed!

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an1  ^Best way to avoid is to take meds at different times in the day +



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