nbme21/Block 1/Question#19
A 22-year-old man has had frequent episodes of ...
C1 esterase inhibitor (binds activated C1r, C1s)
notadoctor
Thought this was a trick question as C1 esterase deficiency also results in a decrease in C4. However, the second answer choice was not referring to C4 but to C4 binding protein, which I now know is different. I also didn't realize C1 esterase was technically a complement protein.
+3 2019-06-09T01:07:52Z
youssefa
Based on many sources hereditary angioedema does NOT cause a rash (urticaria) which is a main differentiating point between angioedema and allergy. This mislead me in this question. Any clarification?
+ 2019-07-16T08:55:54Z
to snoo-finity ... and beyond!
submitted by mcl(132), 2019-05-25T02:50:31Z
Patient may have hereditary angioedema, which is associated with "recurrent attacks of intense, massive, localized subcutaneous edema involving the extremities, genitalia, face, or trunk, or submucosal edema of upper airway or bowels". The article goes on to say "C1-esterase inhibitor works directly on the complement and contact plasma cascades to reduce bradykinin release" which is also probably good to know.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666183/