NBME 21

nbme21/Block 2/Question#39

A 64-year-old man with bronchospastic pulmonary ...

Enhanced action of the agonist at β-adrenergic receptors

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submitted by wasabilateral(0),

This is what I thought but not sure if it’s correct. There is a UWorld q where it describes co-administration of cortisol and epinephrine. Cortisol significantly enhances the effect of epi because cortisol has a permissive effect on maintaining the adrenergic receptors.


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submitted by 5thgencephalosporin(0),

“The combination of a long-acting beta 2 agonist (LABA) and an inhaled corticosteroid is more efficacious in asthma and [COPD] than [...] either alone. Corticosteroids may regulate beta 2 receptor function by increasing expression of the receptor, restoring G-protein/beta 2 receptor coupling, and inhibiting beta 2 receptor downregulation.”

https://www.ncbi.nlm.nih.gov/pubmed/16113435