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NBME 21 Answers

nbme21/Block 3/Question#9

A 75-year-old woman is brought to the emergency ...

Shrunken eosinophilic (red) neurons

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submitted by visualninjacontender(8),

the infarct occurred 16 hrs ago, from 12-24hrs after the infarct there will be Red Neurons.

tsl19  FA 2018 - p. 496: ischemia -> pyknosis within 12-24 hours. +  
d_holles  yeah the infarct occurring 16 hr ago is key. i zoomed in only on the died 1 hr later +  

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submitted by usmleuser007(86),

CNS Hemorrhage/ damage 1) 12-48 Hrs = red neurons 2) 1-3 days = neutrophils (liquefactive necrosis) 3) 3-5 = macrophages (microglia) 4) 1-2 weeks = Reacitve gliosis (+ vascular proliferation) 5) more than 2 weeks = Glial scar

(note: the pathogenesis is similar to MI and its scar formation; however, the time course for CNS is just faster)