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NBME 21 Answers

nbme21/Block 3/Question#23

A 43-year-old woman dies after a 10-year illness ...

Area labeled ‘C’ (Caudate nucleus)

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 +5  upvote downvote
submitted by hungrybox(175),

Huntington's disease

  • anticipation: she has a similar disorder as her father but died earlier

Remember "HUNT 4 an animal, put it in a CAGe". Huntingtin gene found on Chromosome 4. CAG is the trinucleotide repeat:

  • Chorea, caudate nucleus
  • Ataxia
  • Gloomy (depression)
sbryant6  Side note: atrophy of the caudate nucleus leads to a widened anterior horn of the lateral ventricle. I've seen it worded both ways in UWorld. +3  
sbryant6  Side note: atrophy of the caudate nucleus leads to a widened anterior horn of the lateral ventricle. I've seen it worded both ways in UWorld. +  
foulari112  How would you differentiate this from Frontotemporal lobe dementia +  
temmy  Foulari 112..the ageof the patient and the anticipation cos her dad had it too. Also in frontotemporal pick, you will see personality changes where they act completely different vs huntington where they are aggressive and depressed. +  

 +1  upvote downvote
submitted by kentuckyfan(13),

A labeled image

A/B look like grey matter to me

C looks like caudate nucleus

D looks like anterior internal capsule

E looks like thalamus