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NBME 21 Answers
Which of the following best explains why the use of ...
Myeloma cells do not have membrane-bound surface immunoglobulin
This is wrong. PLASMA cells (mature B cells, the ones found in multiple myeloma) secrete antibodies, but IMMATURE B cells have antibodies that haven't switched classes yet (IgM and IgD).
To clarify - immature B cells have antibodies attached to their membrane.
I should have clarified that I was speaking about mature B cells. Thank You
So because MM has mature B cells, exogenous antibodies can't attach to them. Am I getting that right?
What is an Anti-Idiotypic Antibody?
As shown in figure 1, an anti-idiotypic (Anti-ID) antibody binds to the idiotype of another antibody, usually an antibody drug. An idiotype can be defined as the specific combination of idiotopes present within an antibodies complement determining regions (CDRs). A single idiotope, is a specific region within an antibodies Fv region which binds to the paratope (antigenic epitope binding site) of a different antibody. Therefore, and idiotope can be considered almost synonymous with an antigenic determinant of an antibody.
@sahusema: almost exactly correct, but it's important to note they are talking about idiotypic antibodies specifically because by definition these bind the "idiotype" of another antibody (see definition above)
Idiotypic means --- antibody against antibody. B cells don't have surface antibodies but mere synthesize them.