Teh vreeLnaewi uBkr ltPo si laniym eierntterdp yb ist X dan Y spi chtreeenTt. nesutqio stseta taht ingvig B6 ersiasecn het cttivayi to lraonm ,levles hcwih snema eht cvtaiyit uslhdo be eth smae as het rcema Ho.nl,en eirht Y neerttcip dluosh eb eth asm,e so we aer eetnwbe shcoiec B adn .C A dna D do not vahe eht eams Y tcternipe sa Ham.hrrigen lo tscionrentncao of B6 acudse aiicvytt to cbmeeo almnr,o and so maVx lwil ont eb ghniangc adn we cna elncac A and AD. ash a oewlr amxV nad D hsa a uchm eghihr eaxmThV. eenfefricd weeetbn B dan C si ni tehir K.m iogMvn to teh letf on teh X isax mskea teh Km rweol dna lslet yuo ahtt ytnifafi si g herosih yuo wuodl not eedn remo .6B utB ni rou cesa ftyniafi of eth eznyem rfo B6 is leryal wl,o chiwh si hwy we dnee a ont eorm B6.
nI ymamsu,r ew antw eth maes Vmxa nad a hrhegi eWKm. twna hte "moran"l itativyc ems(a maxv as )rolamn dan we ndee hrgeih ntsmuao fo 6B orf ssccesu i ffynstoia of eth enzyme orf B6 is bpyrobla ryev wo.l
eicohC B has a )-m/K1( vlaeu ocsler ot 0 ciwhh nsaem Km si orwle and tafinify of eth eymzne fro its sutaebrst si rpseu .T isohwl eksma sense sa igvngi rhhegi saounmt of eth "tm"tpeiecvio assuerbtt 6B si eplh.nig
iNgndee "hhgrie esontacc"rotnin of het B6 for enzmye yitvciat si ehratno yaw fo sniagy Km si gehhir cnies rmoe si eurqried ofr 21/ mxva iyvcitt.a dsnraceIe Km ulaves esrutl ni 1/Km ngeib mserall lrosc(e to 0 no teh axsi),-x hihcw is satdomdenert in wrnsea iccheo .B
A o"lanm"r mezney tivciyta ni hte eseercnp fo ghiehr B6 nrnatceistoonc nmesa atth xaVm is ont nggacnh,i tub mK s.i
Smoe fo heset xipeansantlo erylal diogn the stm.o If eht enzyme is elab to sairncee to mnlrao titciyav wiht a eighhr eellv fo the reust,abts htta asmen ew’re ni a votictpeemi oibriihnt ttni.siuao Civtomitepe aslywa csrsose on hte a,hpgr so we anc iieelmtna A dna D.
wNo we yaelazn Km. We awtn lmlas mK’s orf tteonp sne.emzy Szei sode nto lwaasy tertam .😉 teExpc ni hist csae ew t’nod twna taht o,cnyept ew ntwa to ookl orf a lle/ayr(1 gbi ),Km (uevla ttha si slorec to ,r)oez bc we antw a ewak igb mK ot be aleb ot rvoproeew teh mivepeotitc bnhitii.or gromCpina eth mninagier 2 oh,eccsi B sah a mK uvela rclsoe ot zreo so shre’te uryo wasre.n
roF htsi ut,qoiens I asw itnkngih ttah yeht dekas uyo oaemrcp to a ar“nl”mo snoepr, os eht xmVa n’uldwot ghnaec siecn yteh sttae thta shi tiyicavt rstuern ot a moanlr elv.le ylnO teh saxxi- dlwuo cesin ti uowld be ta iecdensar tconriscnnetoa in roimscnp.oa
oS i nodfu htsi otniesuq duci.ol.risu. hte xipoansaelnt vrepidod did ton ylearl elrca it pu for ,em tbu i khnti i eadusrtndn it nwo eeas(pl coctrre me if mi' .o)rgwn
Fsrti nad msfto,reo I'm nto even srue fi tsih si urlyt a ewrakunibre-eelv otl,p niesc het Xsiax- si not .Km1/
u,Bt omer ,laegyernl I rtdei ot ndrtnaeusd awht dhepnpea at boht stmereex fo ]PLP[ nad l.oetVicy
:Ps PkLA fuoyres:l hewre no hte raphg si L[PP] eh?gthsi le,Wl if the -sXxai si ueqla ot 1/PLP, PLP wlodu eb ta tsi hhisgte at eht evlau tsceosl ot 0 on het ix-a.xs :tkhn(i htaw is 1 edvdiid yb a blolnii? YERV CEOSL OT ROZ.)E shTi wdluo rersnoopdc ot a piton lnago the is-axy rof eth zeemyns avctiyt.i nI ehrot ,wodrs LPP si at tis ghsehti toiaertconnnc ta eth phgsar ecptYr.etni-
Rebemerm tahw we olsa d:sia nehw het auetmtd eyznem is adruno slot of P,PL it biaclsaly ntciofnus kiel a mnl mezney. Tish nm,eas ttha het Vmax of hte teadtum neeyzm is eatlqeunvi to hte xVma fo eth amrlon nye.ezm ,roTreeefh hTe /xm1aV fo hbto esnzyme ear qv.la.te.uien at the -icey ie!npttrshT is !gbi If ouy teg hist ra,f tehn you anc letiaeimn )A( and ,()D esnci eehts rapghs vaeh fdnetierf trteip-nYsce ndfrie(tfe xmV-e)sa rof ehrti rtesveceip yeme.nsz
ngiMvo .n.o.
lVetyico V)(: W enh V si at its ishgeht (e..i x)ma,V hte eulva of 1V/ woldu be ta sit s.olewt :iang(A inhkt of it cyl:caaltrpi whta si 1 eddvdii yb 1 iioll?bn 0~!) ohe,eeTrrf the lueav of 1V/ is at tsi eolswt nwhe eth axy-is si aueql to .0 oT,heefrre Teh Vamx of tsih osccru newh eht -siaxy si lcsoe to orz..e. Hrees hte hingt t.h.o eseth zeymnse urqeier nfeirtefd leelsv of LPP to etoreap ta -xm.Va ebreeRmm, eth x-mVa of teh MATTDUE mnezye illw pphena at a hcmu GIHEHR .PL[]P Or ,neolvesryc eht xa-Vm fo hte MALNOR emnzye lwil hepnap ta a uhcm OLWER .]P.[L.P
eb rweaa atth het -axsxi for sthi qesuitno si not "K"m 6t(ivB si nto eht ts ttahaertsub' /]BV.61it[ to ispifym, useebca the xaVm is ongan asty teh emsa, yuo tjsu eden to eansicre 6tv]B[i to egt eth mesa Vxma a(ak tfhsi ot rithg no het xa)x-i.s tDn 'o eb floeod doanur yb eth etosqiun t.reriw
dNboyo hsa eeasndwr siht oieuqtns htrouhg eht slne fo a irnlagne tecjoeivb iuetq ety so 'srehe my 2 sntce: Km is DIARESENC bc stih iatpnte hsa na emznye whti na lovlaer RLEOW aftifniy acn( eb trcrcoeed ot noraml tarfe an nsraecie in ast)beurst chhiw is hrscrcateitcai of CIMITOEVEPT oiii,tnhibn whhci si hwy het niel of het pt. is oen fo vetoimtcpei bointiniih no a BL lopt
hTe uqeniost is cbsllaayi eitstng pu a onaiutist rliaism to atht of a pmtievicote riiibhnt.o yehT say that hrgieh roenniatcocnst fo xaoiydplr hptespoah rsesiacen eht avciyitt of hte enzyme ot lmrona ve.lesl lalSirmiy, ehnw yuo aehv a tetpmeocvii iiorinthb adn seaernci eht noctcnreoatni fo ttsrbus,ea hte eenymz cna eciehva het msea maxV as if ohtuitw eth bnith.rioi
rmemebeR 1) itptcevoeim tisrohibin ~ ilnes rCsso ta eetin- rs)ytc2 oe-icipNmttnvoe hobsnritii ~ no elni scros
Lgno esanwr aehd,a ubt rbea tihw .me
INH:T v olkso nidk of leki ,y saehwre k ksolo rmeo leki .x
treteipc-yn = m1/xaV
riecpetx-tn = Km1/
tNoe hatt ,mVax sa a useearm fo ofcerme,npar cna eb ealetrd gohturh aymn n.shtgi enMlw,haei mK is a est eiriartschactc fo eht ,yemenz nda tnonac be dateel.r
In hsti pleamex, hte eneyzm necapfeorrm ma)V(x is sndaecire yb ainnegisrc teh natmiiv crootfac so atth it creaesh a lonam"r" ia.tyictv oH,vwree het nmyzee is sltil thnyerinle tihyst ued to a nocgtanlei ftd,cee so hte Km ysast het m.sea
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