NBME 21 Granulocyte colony-stimulating factor (NBME Answers)

NBME 21 Answers ↦

nbme21/Block 3/Question#38 (36.1 difficulty score)
A 28-year-old man develops a temperature of ...
Granulocyte colony-stimulating factor🔍
tags:

Tutor box

Members from the Leaderboard offering 1-on-1 help:

drdoom / drdoom.tutoring@gmail.com 📩

Want to be listed here? Email us!

+5
submitted by yotsubato(1030),

unscramble the site ⋅ remove ads ⋅ become a member ($39/month)

ehT eanttpi hsa eueNrnicpot erv.ef CFSG lwil retsoer ihs ns.troelhiup

yotsubato His RBC and platelets are low, but at acceptable levels for someone undergoing chemotherapy. +20

+4
submitted by rainlad(23),

unscramble the site ⋅ remove ads ⋅ become a member ($39/month)

ulowd we eb iowrrde uaotb iusgn FCSG- eignv atth he hsa tueac meau?lkei uwold ti uiattemls ohtwgr of hsi cnerca lles?c

suckitnbme I think we're assuming that we eradicated the leukemia with the chemo. However at the same time a lot of normal stem cells were also killed off so we give GCSF to help recovery especially since they have an infection. +

+1
submitted by haliburton(214),

unscramble the site ⋅ remove ads ⋅ become a member ($39/month)

I hosce -CSGF seebauc het teuglyoanrcs deemse to me orem fo a krsi hnta eht etdaemro maia.ne iootthiprEenry semse ilek an atapiorperp hcoeci as llew btu -CFGS mreo acrct.lii

kentuckyfan I think it's also because he has an infection (since he was prescribed antibiotics) boosting the immune system is more important than increasing platelet count E) or RBC count A) +5

+1
submitted by anjum(17),

EPO --> RBC's

TPO (romiplostim --> Platelets

G-CSF (filgrastim)--> Myeloblasts (neutrophil, basophil, eosinophil)

INFy --> granulomas

IL-8 --> neutrophil chemotaKxis

As @yotsubato mentioned, pt has neutropenic fever. That is priority for someone undergoing chemo.

djeffs1 I just didn't know which was more important, fixing his low hemoglobin or his leukopenia +