nbme21/Block 4/Question#29
A 22-year-old man comes to the physician because of ...
Formation of destructive free radicals
sweetmed
or metronidazole
+ 2019-06-20T02:47:20Z
niboonsh
what would his diagnosis be tho?
+ 2019-06-21T22:44:19Z
lostweightthxnorovirus
@niboonsh Giardia I believe. the trophozoite is pictured in the problem and has a classic "shield-like" appearance. FA 2019 pg. 155 has more information and the sketchy for it was really good!
+1 2019-06-22T10:07:22Z
nwinkelmann
Per FA, DOC for giardia = metronidazole. MOA of metronidazole = formation of toxic free radical metabolites in the bacterial cell wall that damage DNA making it bactericidal and antiprotozoal. Metro treats = GET GAP = giardia, entamoeba, trichomonas, Gardnerella, anaerobes (below diaphragm), and H. pylori (as an alternative to amoxicillin in PCN allergy). Adverse effects = disulfiram-like reaction, HA, and metallic taste. I didn't know what Tinidazole is, and found out it is of the same drug class as Metronidazole, so makes sense why it would also be used for Giardia. For the purpose of the UMSLE 1, though, I think metronidazole would be DOC (especially because tinidazole isn't in FA).
+ 2019-07-05T19:02:27Z
submitted by vlodkadrinker(6), 2019-05-15T01:24:53Z
tinidazole preferred due to single dose