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Retired NBME 16 Answers

nbme16/Block 2/Question#25 (reveal difficulty score)
On three separate occasions, a 25-year-old ...
Partial agonist at angiotensin II receptors ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: pharm repeat

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submitted by โˆ—the_enigma28(69)
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Drug X alone has an increase in blood pressure, so it must be an agonist. When you use Angiotensin + Drug X pressure increases but not as much as would increase with Angiotensin alone. This indicates that drug x is probably a partial agonist, since a partial agonist in the presence of a full agonist works as an antagonist [No effect of Angiotensin and only raise in BP is due to effect of Drug X]

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