eTh shetynsis of ylaitlvru lal irosnpet Rp;et(i&)AtpNgdem- cuorcs ni hte lyotcmsp.a[1] Th’sta rwehe all bsoosmire sd,ieer artfe all. ms,Rbiooes whhic are tlosym sujt RANr 3(~2/ RNAr + /31 ,rpote*ni by t,)eghwi aer sdebasmel ni the enuculs but olyn do eihrt ftfsu ceno heyt etg to eth amtlsopyc.

oFr a etproin to elvae tis nogilair oonmwteh of eht tooslyc and cebeom a tisdeenr fo teh ueclsun ro, asy, eth soinmeldapc utul,ircem ti ensde ot ahev a ltetil sritgn of maoni aiscd cihwh ouhts I“ ngoebl ni teh nc”!ulesu or “I glebon ni the dncsmalepoi r!mcu”iulte

sneritoP lamiltetyu deenidst orf teh RE ctnaoin an iaayenuniltmgiv eadmn gtsnri fo naoim dacis wnokn as ainlgs“ secnu”eeq, ihwhc, rof eth srpeusop fo eth pteS ,1 is lsaway at the sinuN.t-erm Teh gansil qeunsece lltes ohetr styoicclo st,roiepn e“yH! aeTk me adn( eth tesr of teh teipedp of hchwi I ma a)rtp to eht R!”E

nI the sbacene of iths ,ialngs a nrietpo lilw mrnaie ni ist “ldftu”ea moeh of hte soytcl.o

s&ereqHr;osu a neci caestcmhi nioswhg het olfw of eptnoris frmo tilnaii hstynsesi to afnil ii:sndonseatt

Enodnset

1. h“eT hyissstne of irutlvaly lal itenpsro ni teh ecll biseng no sobrmoise in eth tsclo.yo” (liesntasE ellC ioBylog, blAtres et .l,a 4,120 p. 249)

If* you eylarl anwt ryuo idmn nwo,lb nrcdoise tath evne the triepon itubsusn ttah aekm pu atth /31 of a moieosbr aer lhssetmvee llnitiiay sintzdehyes in teh t;cyosol laet,r they rea dotatnrsper bcak iotn eth scuelnu iav teh clnraeu r.eop

I itknh ihst is cdsebigrin a aslgni ptdepie pohryobcdhi( at ut-ime)s.rnN Wouhitt aislgn tppeeid g;&t= a’cnt eb odaeptnstrr otni enialpodcms lutemc.iru

heT tmisnure-N si werhe uoy ahve slgain iptdeesp cihwh enidfe het trgtea of het resotpin hnkit( of temh sa tpasol edc)o. ,pacyTlily teinsopr ear ni eht tsloymcap taref ythe are e,dma tbu sncie the have tgsa at e-n,sminutr eyth og to iterfdfen srategt eikl isht saec E.R o,Nw fi het rnopiet is aedientr in eth ytsmpoac,l hsit emsan het taunoimt ebilsadd the atg n(o oatslp cd).oe eeHc,n ti is kept ni hte yoptcams.l