eTh yshssntie of yruvtllai lal spiorent )Rdgtp&(Aep;im-tNe ocrcsu in eht acpsmtoyl.]1[ shta’T rehwe all oeirmsbos seerd,i aterf l.la moeb,soiRs ichwh aer mytsol ustj rNRA /3~2( RNAr + /31 etr*p,ion yb ge,i)htw rea mlesabesd in eth ucseunl ubt olny do iehrt tffus coen tehy egt ot the yso.ctpaml

rFo a enirotp ot leeva ist iioagnlr honetwom of hte socytlo dna ceobme a dernsiet of hte eculsun r,o ,asy eth eodiacmpsnl u,ictlrmue it sende ot aehv a ltliet gtisrn fo nimoa siadc hwhci othsu “I onlgeb in teh c!nulseu” or “I nogble in eht nclapodsiem !cemul”rtiu

iPrsteon taetulmyli etnesdid rof eht ER ninctoa an igtnnulvaeiaimy deanm ngrsit of imano dcsai ownkn as i“ngals ucq,”ensee whih,c rof eht sueopspr of the Step ,1 si swlaya at eht -ni.ersumNt ehT ganlsi sqceeeun telsl hoert yotcsoilc nrts,epoi eHy“! aTek em adn( hte tres fo eth dpeepti of chwih I ma tapr) to teh E!R”

nI teh sbeacne of tsih a,gnils a teopnir iwll emrani ni sit l”ea“tufd meoh fo eth c.lostoy

r;sequre&sHo a einc accehmtsi gnshwoi eth wflo fo orspniet romf tlniiia yssnesith ot nfali :ietstansidno

sEdtnnoe

1. e“hT ssysenith of lvaiyrutl all rsoetnip in teh lelc iegsbn no oessmrobi ni het stl”yoo.c (ssnltaeEi Cell oiglyoB, bterlsA te la., ,1204 p. 42)9

*If yuo lalrey ntaw oyru dnim nob,lw dserncoi thta neev het eropint usiubnst atht aekm up that 3/1 fo a reobomis rea ehltvmssee lnyiialti iteesdsynhz ni the syot;col re,alt eyth aer ttprnoerdsa kabc tion teh cnsulue via eht nueclra ep.or

I hkitn hits is sigedinbrc a singla eppitde dc(yhibroohp ta irt-smNn)ue. uhtWoti glsain ipdtepe =t&;g ct’na be noderstpart into ldcoseianmp cuirlmte.u

ehT tmiue-srnN is eherw yuo hvae aisgnl pesetipd ihcwh efdein teh ttarge of eht tprensoi h(inkt fo hmet sa oaptsl dce.o) yyacpllTi, eotipsrn era ni the tpsocylma ftrae teyh rae eamd, tbu cnesi het aveh tgsa at -n,rtsmunie yeht go to nfietrfed teastrg keil this easc ER. Now, if eth iproten si erdiante in hte lmaptc,yos isth easmn teh inamtuto adieblds teh gta o(n aptlso .ode)c necH,e ti is etpk ni eth lopysamct.