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NBME 20 Answers

nbme20/Block 3/Question#19

A 23-year-old man comes to the physician because of ...

Area labeled ‘B’ (Mitochondrion)

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submitted by lianallado(2),

This patient presents with a mitochondrial myopathy since the disorder is inherited from the mother. Mitochondrial myopathies show “ragged red fibers” on muscle biopsy due to the accumulation of diseased mitochondria in the subsarcolemma of the muscle fiber.

katsu  Mitochondrial myopathies—rare disorders; often present with myopathy, lactic acidosis, and CNS disease, eg, MELAS syndrome (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). 2° to failure in oxidative phosphorylation. Muscle biopsy often shows “ragged red fibers” (due to accumulation of diseased mitochondria). +  

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submitted by usmle11a(11),


guys this video explains alot

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submitted by usmile1(12),

does anyone know what the structure E is pointing to?

thomasburton  Not sure looks like it might be free ribosomes or other such small cytosolic structure (I picked E too, thought B looked way too big!) +  
targetusmle  same here!! marked e thinking of it as a mitochondria +1