Pyruvate Kinase defect leads to decreased ATP leading to rigid RBCs and extra vascular hydrolysis. Increased levels of 2,3-BPG decreases hemoglobin affinity for O2.
For this one you just had to know the glycolysis pathway. Stem told you 2,3-BPG is elevated, which is upstream of pyruvate kinase.
submitted by est88(4), 2019-05-13T20:40:51Z
Pyruvate Kinase defect leads to decreased ATP leading to rigid RBCs and extra vascular hydrolysis. Increased levels of 2,3-BPG decreases hemoglobin affinity for O2.