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Retired NBME 21 Answers

nbme21/Block 4/Question#31 (reveal difficulty score)
A 48-year-old woman comes to the physician ...
Paracrine stimulation of osteoclasts by osteoblasts ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—tinydoc(276)
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ptrydyrhieoaasiHrpm ciasnug bnoe niloess is via tobtlssesOa gnseciainr NRKA L- peornssiex to ndbi to NRAK no tsacsetOsol dna tisuamtglni hmet t-;g&-- icn Boen pisnoeotRr

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pg32  ekidcP D tpieesd etanidudrngsn eth veaob ^^ ucsbeae 1LI- si loas okwnn sa oloettscas viiaicgattn fo.rc.ta. +8
plzhelp123  ^ I ddi het ,msae utb it aappers hatt L-1I astactvie tseosoasclt ni lmipetul oymla.me hcWih masek nsees as taht si a sponaeml fo unmmei celsl whcih nca uprdeco teelnk.rsuini +
caitlyncloy  anc eynnoa xlipean why ihst hte aneswr is N"IERAR"CAP t?miuotsi?nla I ulre tou the teorcrc aesnwr aecsbue i aws itnirgcup KRAN nad AKRN L bid,gnin wihhc is ton rnec!arai?p +1
caitlyncloy  .oh. ti emse NAKR L is edrsetec ot citetaav teh t.slsa.c i swa pnrgiuict ti sa RALNK wsa on hte rcsufae of teh t.blsa ecnf er:eer .?h.tmo/w//wtps=uuwcttshceebhJ:OtIaevoyBAwR +1
makingstrides  fI ouy cn,a I dlWuo glihyh onceedmmr iloognk at teh ythscke mrpah for ihst. It lisapnxe this we,ll in ym o,npnoii nad nyflediite dhelep me. +
jatsyuk38  ajGoln I duolvce' swnor disa HPT eutmatliss eablotossts ot sceerte IL1- to vcettaai toseactols.s He lsoa iads geetsron peensvtr oospisteoros by ngthiibiin toabsltseo esaerle fo h.ew.1erLvI-.o rtehe si loas a odrUWl nuoteiqs eewrh ti sida NKRLA- aypsl a erom otirtmnap oerl oatrc ove(r I1-)L in HPT etamdeid ebon erwbaonkd +1

Primary hyperparathyroidism: overproduction of PTH by parathyroid chief cells Effect of PTH on bone โ†’ increased bone resorption โ†’ โ†‘ release of calcium phosphate โ†’ โ†‘ calcium levels Induces RANKL expression in osteoblasts โ†’ binding of RANKL to RANK on osteoclasts โ†’ activation of osteoclasts Induces IL-1 expression in osteoblasts โ†’ activation of osteoclasts" Amboss

Not sure why D is wrong

+/- alexv0815(10)

Primary hyperparathyroidism: overproduction of PTH by parathyroid chief cells Effect of PTH on bone โ†’ increased bone resorption โ†’ โ†‘ release of calcium phosphate โ†’ โ†‘ calcium levels

Induces RANKL expression in osteoblasts โ†’ binding of RANKL to RANK on osteoclasts โ†’ activation of osteoclasts

Induces IL-1 expression in osteoblasts โ†’ activation of osteoclasts

Not sure why D is wrong

+6/- alexv0815(10)


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