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Retired NBME 21 Answers

nbme21/Block 4/Question#31 (reveal difficulty score)
A 48-year-old woman comes to the physician ...
Paracrine stimulation of osteoclasts by osteoblasts ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—tinydoc(276)
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eihodarsipatHyryrmp cnsigau ebno nsoseil si iav aossOlbstte agnisencri NAKR L- eonseprxsi to bnid to NARK on ssaOettlcos dan tmisnagiltu ehmt t&--;g- cni oneB nsporiRtoe

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pg32  iPdekc D septedi agnreddnutins eth oebav ^^ eceuabs I-L1 is laos nnokw as tolessatoc iatntiicvag rtcaf..o. +8
plzhelp123  ^ I ddi the ,maes but ti ppaaesr ttha L1-I aacsteitv sotaoecltss in leiutlpm l.omamey Wchih eakms snees sa atht is a nlaepoms fo nimuem slecl wihhc anc duorecp tnlkei.isrneu +
caitlyncloy  can nonyea lexpani yhw tihs eth awnres si NCRPAIAE""R nt??oimilaust I rule uot eht eotrcrc nsrwea ceuasbe i swa tcngirupi AKNR nad RAKN L b,gidinn chiwh si otn !nirparc?ae +1
caitlyncloy  oh.. ti eesm NKRA L is srctedee to atctaiev teh c.s.tals i swa tipgnciru ti sa LRKNA saw on teh cerfusa fo teh .salbt e:cfeee rrn =OwecmIBwc/JhwatRhe/t?sboAwpo:.uhs/.yttuevt +1
makingstrides  If uoy cna, I dloWu hhlygi dmrnoecem onkogil ta het ctskyeh mphra ofr h.tis It ispnaxel hits ,llwe ni ym ono,iipn nad yfdeiintel hpedel me. +
jatsyuk38  Galnjo I vudcoe'l owrsn idsa HPT utmilstsea asseolttsob ot eertsec 1-LI ot etaaitcv s.tsteocalos He slao asid sgoerent rpnsveet tospsorsieoo yb tbiniiighn leostsbtoa reelase of -e.Iervw.1hL.o rthee si asol a UlrWdo utoenqis hrewe ti aids KRLNA- splya a omer trnipotma elor aorct vreo( )L1-I ni THP dtmaeedi boen denwaorkb +1

Primary hyperparathyroidism: overproduction of PTH by parathyroid chief cells Effect of PTH on bone โ†’ increased bone resorption โ†’ โ†‘ release of calcium phosphate โ†’ โ†‘ calcium levels Induces RANKL expression in osteoblasts โ†’ binding of RANKL to RANK on osteoclasts โ†’ activation of osteoclasts Induces IL-1 expression in osteoblasts โ†’ activation of osteoclasts" Amboss

Not sure why D is wrong

+/- alexv0815(10)

Primary hyperparathyroidism: overproduction of PTH by parathyroid chief cells Effect of PTH on bone โ†’ increased bone resorption โ†’ โ†‘ release of calcium phosphate โ†’ โ†‘ calcium levels

Induces RANKL expression in osteoblasts โ†’ binding of RANKL to RANK on osteoclasts โ†’ activation of osteoclasts

Induces IL-1 expression in osteoblasts โ†’ activation of osteoclasts

Not sure why D is wrong

+6/- alexv0815(10)


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