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Retired NBME 21 Answers

nbme21/Block 4/Question#31 (reveal difficulty score)
A 48-year-old woman comes to the physician ...
Paracrine stimulation of osteoclasts by osteoblasts ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—tinydoc(276)
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irroespHitrhaayymdp sucagni nebo neloiss is avi oslabesstOt cansiering ARNK -L spexeniors to bndi to RAKN on etcassslOto dan gamuslittni hmet g-&;--t cni eBno ieonoRtsrp

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pg32  kciedP D epsiedt inantdsrgendu het veabo ^^ ueaebcs L1-I si loas nknow as saotscloet gviitaiatcn ..artoc.f +8
plzhelp123  ^ I ddi the sm,ae tbu ti asaeppr atht -IL1 aiasvctet ttsscaoesol ni mileuptl aylmm.oe cWhhi ekams nssee sa hatt si a nslpoame of umneim csell iwchh anc ducoerp leuntkns.riie +
caitlyncloy  cna yneaon enlpxia hyw isth teh erwnas is RR"EAA"PCIN o?timual?tnsi I uerl tou hte tccroer wnsera cabseeu i swa gritnicpu NKRA nda RNAK L ,bgiinnd cihhw is nto r!eniar?acp +1
caitlyncloy  o..h it emse NARK L is creeesdt ot taveiatc teh cts.las. i was rcuitnpgi it sa RNLAK was no eht csaufer fo het slt.ba nrce: eefre RetvBowacehIAp=w.wottc/sshutOJ.w?hbym/u/:te +1
makingstrides  fI ouy ,can I uoWld lyihhg mmoceednr ogkinol at teh hektsyc rpham orf s.iht tI nlsxeaip isth ,lwle in my noi,inop nad ntlyifeedi eepldh m.e +
jatsyuk38  alGonj I devuocl' srwon iads PTH listaetsmu atolosbstse to ceetsre L-I1 to atvceati otalssosce.t He loas isad trgenose enpvesrt soietrossoop yb gnhiibitni lstetosboa eraeels fo wI..1.vehorLe- hetre si osal a rlUdoW tiqnoeus ewehr it said NLKRA- aplsy a more airmptnto elro atrco (vore LI)1- ni HPT tiaeeddm boen nrawobked +1

Primary hyperparathyroidism: overproduction of PTH by parathyroid chief cells Effect of PTH on bone โ†’ increased bone resorption โ†’ โ†‘ release of calcium phosphate โ†’ โ†‘ calcium levels Induces RANKL expression in osteoblasts โ†’ binding of RANKL to RANK on osteoclasts โ†’ activation of osteoclasts Induces IL-1 expression in osteoblasts โ†’ activation of osteoclasts" Amboss

Not sure why D is wrong

+/- alexv0815(10)

Primary hyperparathyroidism: overproduction of PTH by parathyroid chief cells Effect of PTH on bone โ†’ increased bone resorption โ†’ โ†‘ release of calcium phosphate โ†’ โ†‘ calcium levels

Induces RANKL expression in osteoblasts โ†’ binding of RANKL to RANK on osteoclasts โ†’ activation of osteoclasts

Induces IL-1 expression in osteoblasts โ†’ activation of osteoclasts

Not sure why D is wrong

+6/- alexv0815(10)


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