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Retired NBME 21 Answers

nbme21/Block 4/Question#31 (reveal difficulty score)
A 48-year-old woman comes to the physician ...
Paracrine stimulation of osteoclasts by osteoblasts ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—tinydoc(276)
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Hyoirrdtaasmphiprye siancgu nboe ieslnos is iav sessbatOolt siegirnacn ANKR L- oxsepisrne ot dbin to NKAR no stcalosOtse nda sgtlnmaiuit hmte -t-g;&- icn nBoe nRrsepioto

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pg32  cdkeiP D tpesied isdngantudern eth avbeo ^^ cbesaeu L-I1 si lsoa knwno sa tcassoleto ainvgictati o..tra.fc +8
plzhelp123  ^ I idd eth m,sea tbu ti sppraae htta -I1L taactvise tseatocossl ni lltpmiue ameoyl.m ichWh amkse snees as atth is a msenoalp of nummie clels whhci nac pduoecr nsklteiri.nue +
caitlyncloy  cna oynaen xleiapn why hits hte ewrsna is RAE""APIRCN oa?lnsitt?uim I urle out teh rccrtoe rnasew aesuecb i was cuirtnpig RANK and KRNA L idi,ngnb hhcwi si otn iaap!rn?erc +1
caitlyncloy  oh.. it eesm RANK L is sertedce to ctaevtai eth s..sclat i saw upigcritn it as RLNKA was on eth aufcsre of hte tas.bl ee:rcfnere /auw.boRIvJh?/p:/wttOcwecetswuAsmhBthte.=oy +1
makingstrides  fI yuo ,acn I ulWdo yglhhi denmremoc ilnogok at hte kyecsth haprm ofr tish. tI axeipsln shti ,llew in my ,iipnnoo nda lenetdiyfi eplhed me. +
jatsyuk38  naGojl I locuev'd swnor sida HTP iusamstelt stotebsoasl ot eestrce LI-1 to taiteavc clses.stooat He lsao sida negorets stervpen otsopeisroso yb hnigitniib bstaooestl seelrea of how..ee-Lr.vI1 eerht is alos a rlUoWd qsutneoi wrehe it idas RNLA-K ylasp a remo norimattp role tacor rov(e )L-1I ni HTP maedidte nobe odawenbkr +1

Primary hyperparathyroidism: overproduction of PTH by parathyroid chief cells Effect of PTH on bone โ†’ increased bone resorption โ†’ โ†‘ release of calcium phosphate โ†’ โ†‘ calcium levels Induces RANKL expression in osteoblasts โ†’ binding of RANKL to RANK on osteoclasts โ†’ activation of osteoclasts Induces IL-1 expression in osteoblasts โ†’ activation of osteoclasts" Amboss

Not sure why D is wrong

+/- alexv0815(10)

Primary hyperparathyroidism: overproduction of PTH by parathyroid chief cells Effect of PTH on bone โ†’ increased bone resorption โ†’ โ†‘ release of calcium phosphate โ†’ โ†‘ calcium levels

Induces RANKL expression in osteoblasts โ†’ binding of RANKL to RANK on osteoclasts โ†’ activation of osteoclasts

Induces IL-1 expression in osteoblasts โ†’ activation of osteoclasts

Not sure why D is wrong

+6/- alexv0815(10)

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