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NBME 22 Answers

nbme22/Block 4/Question#17 (15.9 difficulty score)
A 62-year-old man with dyslipidemia is ...
GemfibrozilπŸ”
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 +2 
submitted by castlblack(50),

Highest yield drug combo to avoid on NBME, Kaplan, and UWorld.




 +0 
submitted by luckeroo(7),
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wyh was tihs zogmelbiirf adn ont nniai?c I was kcuyl dna deseu,sg utb I hothtug aninic beidcomn ducol osla tgierrg ayh?ypmto

.ooo.   Gemfibrozil is a CYP450 inhibitor causing an increase drug concentration of statin which would lead to the adverse side effect of myopathy. Not sure about niacin in combination with statin but believe this would be more likely to occur. Hope this helps! +1  
yb_26  yes, it can be seen with niacin and esetemibe as well, according to UWorld. But first choice in such questions is always fibrates. +  
nor16  number one no-go combi is statin+fibrate here +3