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NBME 22 Answers
Nicotinic acid acts at which of the following ...
Pathway labeled ‘C’
Well color me surprised. I was completely thrown off here.
1) label D (VLDL -->ILD --> LDL) = anything that increased LPL = Fibrates which use PPAR-alpha (Rx) are good at reducing [VLDL]; therefore, less VLDL means more ILD.
2) VLDL --> fatty acid oxidation = using fats (TAGs) for energy production
Here PPAR-gamma plays a role= which are Thiazolidinediones (also called glitazones) are a class of medicines that may be used for the treatment of type 2 diabetes. They are also good at reducing serum TAGs
Note VLDL are very rich in TAGs