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NBME 23 Answers

nbme23/Block 1/Question#35 (reveal difficulty score)
A 42-year-old woman comes to the physician ...
Binding of permeable ligand to nuclear transcription factor ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–

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submitted by โˆ—beeip(141)
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ehT tbse I cna ddtsnu,aenr r'tehye crsgebnidi aimtolnedre saypleihapr, a tsrleu fo ecssxe ,teosrnge a roisted ernmooh ttah ecslarntsaot ot teh luucsne nad dbnsi tis trictroainnps c.torfa

mousie  My exact thinking also! +7
sympathetikey  Ditto. +
meningitis  My thought as well but the answer says: "Binding of ligand to Nuclear transcription factor" and I thought to myself: "Estrogen Receptors aren't transcription factors.. they are receptors with Transcription Factor function that bind to the ER Element and recruit more Transcription Factors". Can anyone explain what I am missing? Am overthinking things? +
criovoly  You are overthinking it, Steroid hormones receptor is found intracellular in the cytoplasm then they are translocated to the nucleus where they regulate gene transcription. HOPE THIS HELPS +6
eve1000  Could this be due to the PTEN gene being linked to endometrial hyperplasia? +
feochromocytoma  The question stem says it's glandular hyperplasia "without" atypia It's just due to increased levels of estrogen causing the hyperplasia +4
faus305  This is a bunch of scientific mumbo jumbo +1
chaosawaits  ^^ I read your name as "ugly chromocytoma" and if that was intentional, buena onda +

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