A vrey slairim euoiqnts I ehva snee ni anQsbk lwli sak why a atitpne whti rhtgi tahre freiual deos ont eoeplvd adeem dan het wnears is eidcanesr ylahcmitp r.gaedian I tgo tshi utoisenq wgron ilnirgloay eeubacs I nwsderae ngloa isth eiln fo erniaongs tub I hknit ni tsih csae ti all ahs to do wiht WEHER eth etrxa pesruser is icmnog o.rmf nI htis utnsqioe hte tp ash istaodicl iohprestynen so ouy can ihktn aoubt eht serupser sa onmigc d"orwr"af so grinntstoicc ilarylaeprcp irtcsehnsp acn tenvpre na insacree in reuersps in hte aalycrpli eb.d eHwrevo fro rghit eathr afuirle sith xatre ildfu si mgnoic rfom het POPSITEO rdinciteo d(askarcbw omfr eth ihgtr h)erta and isinotgctcnr pcaiyaprlerl psitrcsenh nac od onnthig o(n tpipooes sdie fo lparycail be)d - the oyln wya to tnrpeev aedem is ot eesinrca mlhtcaypi dgia.nare

sWa it jstu em, or did g"ea at ensot ni yasr"e eraapp RTHIG evoba the muebrn of naetis,tp etharr ntah eht mn.ae hWhic efosnudc me for a gdoo 3 ms.uneit

A dan J srnrepeet the aierlcg sa,luiscfuc ewihl B and I etpnrsere eth uecanet aufclsi.cus Teeogrht etyh keam up teh lsodar mmaulndcoeli- mielalsnc atcrt, beiresolspn ofr ntpipnio terpoecpi,n pcrntooeoppiri, aivrbo,int nad re.sspuer Iutnp is tllrpsai.eai

C dan H kmea up hte lrtalae nioipaocclrts tratc alo(s ledlca eth rtallea elncebsrripao cula)ss,ciuf srobenlpise orf mrtoo mcmnaod fo psleialtiar msibl.

D adn G retnreesp het llartae psictmlhoinaa ca.ttr tI si ssirpblenoe for niap nad tptaerumeer o.uiccndont eTh ptuin easisr ni a ibml (tlfe owlre xttiyrmee in iths c)aes, etners ogtrhuh teh ordlsa toor ctred(piu webneet J dna ,H) edaeucssts nad snsdace ta eth anierrto meoirssmcu s(tuj ehbndi E nad ),F nad niyllfa espanssy no het nscdeo dreor neunor ni eht talelra onaimcsipltah ctt.ra oS eth mascntiahopil trtca is peiebsonrls rfo taelalraornct ipna dan uerrettmpae nsin.aesot seBceau uor ntitepa ash ltos snosenati on the e,ftl eht lineos is in hte tigh.r

E adn F era het rareoint iltoinrpoaccs .ttcar tI is nviovled in rotom tolrcon of rmxioapl cule,ssm lpyatyicl of het truk.n

lCboooma si an eye ibtylonraam hatt csruoc rbfeeo .rithb eheyrT' snsigim peisec fo usiste in usstucrret taht rmof hte .eye

• Cmoaloosb tcnegffai teh risi, hhicw uerlts ni a "ehoel"yk cnapepraae of eth pplu,i gnlereyla od ont aeld ot vonisi oss.l

• bCmsooaol ngnvlioiv het eranti surlet ni isoniv sosl in psfieicc rtsap of the avlsui e.lfdi

• aLegr aneirtl bcmoaolos ro tsheo cfnegaitf eht ocipt nreev nac uecsa owl in,osiv hwich esnam sovnii loss ttah ntocna be loletcymep cetdecror iwht eslasgs or tcocnat lne.ses

hooAllcci = naratpeicc nfiiceyisn.cuf nlioLec,i oilce, nad tilicmpa icad anc eb obarbeds twohiut aincacrpte essplia eicsn rtyhee' ujts efer ftyta aics.d eTcliisreyrdg dnee to be orenbk nwod by aielssp rbfeoe b.paotiorsn

lieB csdia rea eth mani dtohme orf meligantini e,hroletslco nto iartcepanc eznsyem

athW a rrbtieel epirtu.c eyTh eyth voderce up rtap fo ti htiw is.eln TFW

oyu eden ot nwko diff tb niteagev pseerrsu lonvineiatt ihhcw( si nlmroa )lentovtiina adn viitpose surrspees ientntiaolv cwi(hh si chaaenlimc litn.iovetan) nI teavngie srseperu oivlnntatei hte ipmdgahar rncatcots iknmag a - prtleaunairl pussreer wichh loawls voallei to pan.dxe ni ioivpest ltnoteaivin et(h tp iamrhadpg si otn gnontrtacic stuh nto degapnnxi cesht tvyicai dna ont eagticnr eth - )rspueesr eht ehmnaci si ngeairct sveitipo ereusprs diiesn aieollv os os aeolivl pne.axds :)

heT sbte I acn sadreu,tndn ethyr'e iicedgbrns tledmrnoeai aplisrpeyah, a eutlrs of xssece resng,toe a tsredio rmeohno htta cotantasersl ot het suulcne adn bdnsi sit rcipanisnotrt ofrc.ta

raMaail cna rapimi aeitphc eiesougnlgcnsoe nda nac osal muosecn seouclg orf tis wno ematoibcl das.nmed

oS fro dadinCa we can use

sAzole fzl)ocn(loaue nbt(hiii C50P4Y ieyaodnehltmt)

moeAtpcnihr B po(er ntfamroio in alufgn llec erm)menba

ipafuoCnnsg prv(enet rgknsiolncsi of aebt nsglacu in cell lwal)

ro Nanysit ofr oral ro hagsepaleo seacs p(roe moifaort)n

ihTs iotnquse si niysag atht she si iatngk an RLAO rgdu ot teart ndaidac a.nitgvisi

mtieponrhAc si IV

pniufsaCogn is olas VI

os ere'w tfle itwh zsaloe

Azsloe iiibhnt etyhnssis of rlooeergts yb hbtniginii PCY 540 htat orcstenv tlsonloera ot reroeogstl.

iiCatcrl npsiot rfo ihts uqetsi:on 5 arey old by,o usrpdnpeommsuise cseuabe of pryoh,eecmtah 2 yda hsiotry of ,freev o,hgcu hnssreost fo aerht,b berlife 0(81.1 F,) peitrraosins 4/,i6nm iwth yinoscas nda rdielzgaene vcsueliar h.sra vxeintEes aloudnr ontfani.ilitr

fO the sntpooi eslitd nloy eamsesl nda VZV vgie a hr.as A rsah mrfo asmeels lyuauls stsrat torlyslar nad sdescden l,ludcyaa nda si laft nad eeyhmaous.ttr yB tonctra,s ZVV ecochipx(n)k sensrpet wtih lnieeagzedr rhas thta cikyqlu nsasitnotir morf carlaum to lpurapa tnhe to rauecsiv.l

inectnaenaM oesd mlufaro is (sCs × lC × )uat ÷ F

weehr Css si tasdtseey-ta aetgtr asamlp oc.cn of rdu,g Cl si enr,aeccla uat is esgado rteilnva m;&ap F si ov.laiatbybiilia

hiNeter sgdoea nltverai nor yiovbialbtaliai is ,nvgei os onngiirg oehts a;m&p inlpgggu ni hte nbmsrue lerauf(c to oetcvrn nistu ot gmdga)/yk/:

1( =2 Lgmu/ × 1 00mg01/ )gu × 90.0( /h/Lrkg × 1000 1mL/ L × 24 1r/h yad)
= 2952. kygm/gda/

whcih... t'ins ayn fo eht rsaenw hoeccsi edis.lt heyT umst aevh dnoedru 009. h/L/rgk ot .10 L,rg/k/h dna ndiog so vsgie xteaycl 828. gmyad/gk/ hi(coce C)

oN etid ec,nficdeyi hte ptetani dha sexsce recnotea edu ot his itde

lunrisg,rypis I cyuaallt aneedlr this fomr teh aiMcg holcSo Bsu hnwe I saw a k.di sTaht' eht yonl nsaore I otg ihts rhtgi. Tnhkas .sM z!lFeirz :D

He sha flaec ecnctnninoei so ihs axlenter spcinhter is ,amgdaed iwchh si enveidtnar by eht dpnaelud n. (4-)2SS. Teh lepciv ihlnpcnacs venr,es chhwi eatemdi het eorcenti esporsc, rea aols 4-2SS.

Enzyme A datssn in rof soPpiosehlahp 2,A ntnriug lpiohoshpdpsi ni teh elcl mmenearb itno ciicndrahao ascid. Fomr h,eetr zemynE B natssd rfo Conagxsclyyoee )O,(XC hweil nyzemE C satdsn rof -ygep5eosxLian -L5(O.) 5OL- urpecdso TEEPH,5- ichhw si ndteru oitn teknsoelire.u Loeenkrstuie aylp a uodble lreo in nveets elik sa,maht scebuae yhet aseuc coiosonrnntcictrobh n(ese in isth tnea)pit dan yb iatngc as hecaimcl ttrsatactan fro mrtaofynmial lslce, woseh ctvtiayi ilwl coesl het iyaarw r.rtefuh yB biglcnok COX pamlebyusr( hwit an ,NAID)S ew aleve more fo teh srsttebua hioiaarndcc daic rfo OX5L- to atlyutmile cvteonr inot snot.eirkeelu iTsh si eth sbsai rof aahmriassna-nititotlrn,e-p ihhcw is qtrufneyel tesaoscaid htiw lasan oppyl.s s(Stamr'e dat).ri

5tl3rcxea/hTewocFp/tg/sw95:t/k9tull4m.eia/r.wr

)D ylrcinPcoast nhaestsy . E) xoohTbmnaer sthyaesn

Prtserooi ordc eonydsmr ourcsc edu ot ratniionfc fo teh strioerop alhf fo hte nlpsia dc,ro romf ncosliuoc fo het ioeotrspr siplna rte.rya ruO tnatpei setrepsn wiht dercadsee enasnstoi ot pcnikrpi obewl eht velel of eth knsee as wlle sa iaglnwk ihtw a ebdwedsi-a gt,ia lyeilk idgtcaniin sslo of pooptoirprienc. Teh tiaepnt is salo aimnce twhi edtreenhy-pesmg leoruinphs.t

dengeyepsmerHt hnsrtpiuelo are llpiytyca uscade yb an tnylibaii ot kema unoegh ,NAD scduae yb a alkc of ereyacsns ucpssorrre nda isvtmian ndciigunl 9B tleo)af( dan 12B aa.c)onib(lm If het eptniat is lfoaet efi,necidt ew ees tleeedav smieyontohce iedf.eicnyc fI hte epaitnt is 1B2 tednciief, ew see vadleete lntmcleomhayi caid adn ysothciomnee el.evsl cmseenHihirtopeyamyo acn ienaercs rhboomt.iss sosrhomibT ni eht soeporitr nipals erytar nca aucse ierostopr dcro dnrm.esoy nI t,iinodad lkca of tiiavnm 2B1 pmsiiar eyimnl oiafmrton and saedl to aeucutbS nCodemib niDtern,goeea cwihh cffseat hte moSincalaphti atrct nnitouc(agc rof sedcdraee pipkcnir nsats),neoi toCpsnlicorai rTa,tc nda raDslo meadu-lCniolM imssucLen tcraT anc(ociugnt rfo het cerddue cropieip.onoptr

)A eorAitrn ordc -osnyemdr loss of tormo nmamd,oc sa wlle sa blrteaali lsso fo thea nda ni,ap het nipetat sha otn otsl romto ifo,cuntn os ti cnntoa be i.tsh B) naetlrC orcd -msrydeno stenpres sa a tnoaicinmbo fo rotmo adn seornys ,sslo llayuus thwi redabld tcfnyd.soiun iThs teptain osed ton dylasip ortmo sslo ro redabld yfondtciu.sn )C eocmrdHi rmeydno-s oslA dlclea -BerduwaoSrq,n ihst si pcemltoe rnyjui to therie the tlef or thgri sdei fo teh lipnsa ro.cd It repsetsn iwht mtoro nfindcsotyu dna lreexf odsuycfintn lpatlaisyelir at hte evlle of teh n;iloes sosl fo purpe mrtoo doncmma eolbw het esnoil lalsrilatpeyi ctsipa(s s);epiars sslo fo rlaods nlmcrourciae-d snsaniteo alpleryialsit at nda elwbo hte n;lsoei nad lsso fo inpa nad utremeteapr nnssaoeit ntolrraetacllay 2 to 3 vtaebrer oewbl the lsoe.ni )E yntemgreSa dn-emsoyr a igetlnonca euialrf ot pvedoel rtap fo the plaisn or.dc ehT enw netos fo ypsstmom ta 28 ryeas old skmae itsh an eunlyilk .iagnis,dso

tsnW'a erus ouabt iRaettik,cs btu I nkew nroib of xdesio was no shi erliyctc ni teh ersohatnt adn gntteig rodrteut by hte pmvirae sb.eab

heS tsju etcleodmp eht soucre fo iumarib,xt which attgser 20CD cetrpesr.o -cBell ieneycifdc nca perosedisp ot acarbteil c.osenitnfi

b) BM ilerfua si not iaassdcote ithw xuiract ib)m gdnro)w ngwo r)e hits srucoc w/in -107 ayds fo gtaintsr t,entremat and dluwo not rcuoc eftra eplctginmo a tn-mo4h rucoes of mr.iabtuxi

hTe pittnea hsa a iporr ysihtro of htersyoetcym whti lretalabi ecsoolphtnoaoompy,g-ri dan dcerivee lrenaext maeb aatniorid to the peilv.s heT peittna own siapdlys dohhirspsyoner nad er,yrruodeth twhi dltsia lerutera nrnwgario tlar.leayilb The etleisilk ipoont is ttah ew aer isgene oesnhdasi mrof ueiosrvp rruegsy cionsrttc teh uer,etrs sunacig .hits

)E rllhaUtoie mraioncac o(las adllce olannaisirtt clel caincmao)r is aslo a sl.iiobtypis ahWt kesma siht ekynulli si eth toniocal: il.reatlba Teh rriop yeytsohmertc nda tabillare ohgocset-ioonapoyrlmp doulw laeev cras sutsei no thob sdsie of the yob,d but the sodd of ruahletlio rioccamna isgnira iletarbllya are very sm.li

)A eTh taneipt had a etehomcytrys, so eth odsd fo recuetrrn lavricce ccroinmaa rea olas icreybdinl .olw )C dan )D rrhlUate myndloaoc and ualhetrr tnliiartnsao lcle pomillaap rae in eht rwgon ilaotocn to caotcnu for lalebtari rlatrheu ringowran whti erydreuo.rth

To be clplmeeyto ce!alr

shTi tnaitpe ahs tissysinCo a erra usaolaotm rveseicse lsyaomlso torsage ersrdido dna omst conmmo ucesa fo ianocFn enmordsy in .rdcheiln sCiistonys is smictsye nad edasl to yctseni tcasryl oiptsdse in llcse nad sssieut orouhhgutt hte ybdo.

hhtgoAul ssiolnW edsaesi can lade to F,S het ytslscar in teh coasenr osed tno elcetorar wtih lssWnoi si.seaed
r Meo :ifon 8Prpmnn11w..wnv0c/4a.c/gs:tt.ieCl/h/o6Msclipih//mb4wt

Per WLOR-UD edoancoarcAinm si oatsscadie w/ nglu arrsncig tearled to luaoasurnmogt es,eisda dol PDOC (r)hcconi nda agdame ude to nreerurtc maineu.nop

ieAbrablttut ikrs = cdneienic in epeosxd – eniceicnd ni xnupedose

= 0010,/30 oms)ers(k - 00/,3030 soe)o(nkrnms
= .300 - 0.01
= .002 s(o het brteuttaabli rksi is uaotb %2)

lpAgpyin it ot a nioptpulao fo 0:1,000

= 20.0 * 000,01
= 002

onarifaMd tshabiu + aucolMs uormsane + Nkce sams = NME 2B M(MP) eoh,P yreMullda ytdiorh AC inilCatnoc( )ereincst,g cuolsam rneusmao

sTih attpine ahs adpiwsered stetrondicu of thbo raalend ngal,ds ichwh smnea htta seh illw eols ohbt erh milotosradricenoci nad rhe loo.idrcutscocig Teh sols of the aroienmdcclioosrit dan the etffec no hte sdenyik si ahwt is niebg esdtte .eher hWne detoolresan si inutfngoinc nda ana,nbdtu ti ash rleaesv tclciiar nficsuont no teh nroenh.p ri,Fts ti prsuugateel /N++Ka ATsPea seirnxpose no het orabaellast r,aemnmbe hitblseasngi a trnosg acltclcrheomiee naerdgit ttha treebt osbrbsa +aN, ihelw het ciesrande unlerarltalic +K tnintccneoora saekm it iseare ot oesl K+ ormf the cell tino eth nmlu.e nrdAestoole sloa regulsupaet eth sepinosrex of eeiaptillh sdoumi hanelsnc E(aCN) on teh tngcellcio uctd, onraeisrbbg mroe N+a. Fa,llyin seonldartoe eaeinsrsc xesorspein of +H PsAseTa on adnheactlei-trlpaa cslel fo het olegcltnic t,cdu hhciw rae eoebpsinrls for sterncegi +H (itsh is part of icrtaonotnc .laosalisk)

tWhi teh ossl fo r,loeatoensd we illw see a ecesardse K/++Na tnaiergd nda csedraede +Na snrba;tpoeoir tihs aseld ot sadeerdec merus omdisu nad eneciarsd remus otpiusm.sa At het eams im,et ont sgprisnxee +H aTAesPs lwli aled to +H otn ngeib rdeetes,c cgrtaine a emro dcaiic tvenrinnmoe Hp( wlil .s)aeceder

ehT ramorw hwsso surrrsecop ot ryhrecettos,y sa well sa rcegyaaomtkye.s iThs is ot hwos you atht eth ssuei sitn' p,oeuuoicrdndrtn wihch ensam tath we rae lnogis BCR and plattesle reswemeoh ie rcniu.stedot htaT usrle otu D nad E. Teerh is ihngtno to ieaictnd aht hte cdhli ash tdedsisimnea rtoluecbsius (.B) tA shit tionp ew rea ltfe whti A ro C. A uldwo eindtcia Ddessnatmeii ulrsctraavnaI aogonutlaCi CDI() or ontigemhs asmilri, whcih wulod esurlt in olw tatelleps nad RBC tbu we oduwl lsoa ees rnalbmao RBC lkie sctocteisshy ("l"mtehe )les.lc eW rae lyciltxeip tdlo hatt eht syteycrthero ear romncrhimoco adn c.otocmynir wHeeo,vr unimem idrcouetnst of ellttaesp xpseilan ti l-al the onecrdtutis fo ltsltaeep ealsd to osme gohearinmgrh dna os a ordp ni B,CR dna PIT iyllsasclac iesars tfrae a neertc prpue sapoeiyrrrt tarct alvir icnifto.ne

aoa:Phmt - ysytpcoLemh are het msot isstievne esllc to wleho obyd dtonraiia - astoylGercnu (alnyiM tlsnioprue)h era yuripclltaar ryve visenesti ot etaecitmhcuoeprh nygtailalk tgsaen rqe(inirgu -GSFC rstylho eft)ra

rlsaiecV shissaeimanil sceuas nepaaeghlsomleotyp adn tmso mtp,ionayrtl caenpntapyio. It si nftoe ofdun ni eplpeo hwo sivti het deidlM Etsa adn si tatedmrstin yb hte n.Sydalf yWh idd NEBM put 2 nmLsiehaai qsnostuei on itsh mrfo llo

1. aCnecsr fo eth ,ivlspe icignulnd teh tpter,osa sarepd to teh smaboclurla ipens via eth ertrbelav esunov lepsxu )VP(V.

   • hTe VPV nomaiucsmect thwi a ubnerm fo evsnou okrew,nst ncngiliud teh opttsriac eusovn lspuex, ihhcw srvieece teh ovneus slyppu morf hte ,setatrop ,pisen and bearld.d

   • VPV nsur up the inreet sipaln lmocun dan cntcosne thwi hte enuvos upslpy fo hte irabn via a vlaseevsl msseyt so’ntsa(B esul)Px wichh walols rof caiorbndleiit flow adn gitnorulae fo nriicrlnataa pusTihrse.rse ousnev inccenotno ot teh reabcrel urinclicota yam lpeh ailenxp hte psptrineyo of romsut to sztemsietaa to eht arin.b

2. The VPV sloa cueintosmmac wtih the ygoazs envi in het es,cht ciwhh slexaipn in ratp hyw sterba nda ulng snaeccr rfylteenqu ssmtzeeaati ot het hatorcci einsp.

   • ilal,yrmiS ude ot unomalrpy oenvsu negdaair iton the ftel ides of teh a,reht gunl tousrm fotne sarepd atclylsemysi via eht rrtaaeli tsms.ey

3. ulAghhto mhylp ndose era het mtso oomnmc isste fo ittaesasms ni ,enaeglr acyimplth drespa to eht kaeestll msetsy is reyv rr.ea

4. Teh fmairionppm spxeul vreecesi nvseou aadegrin romf hte ,stitse yd,dismipei adn ductus srneefde adn sdanir nito the aeltuscrti nsevi.

gTouh itesoun.q

Rlelac htat mntenaMei zrm(ilesh'ae gud)r is a ADNM oRetrpce angtotnAsi htta lehps trepvne cotiycitextox yb Bglconki +a2C tyner. tTh'sa owh I errmmeeb sti.h

Besucea eht basyb' thoemr ash ypTe 1 bsitDaee eltusi,ml it si ibllpsuae taht eyth adh daevltee oldbo cuslgoe evlles nuridg ro tlyhros rebfoe tbhri. nlIisnu esod tno soscr het nc,paelat tub ogcleus ods,e os ugirdn ihtrb the noneeat ulodw hvea nbee relhmyci.epgyc sihT olduw dael ot het antenoal sareapcn egelrsina iusnil,n rgdniiv clougse oint elslc dna ugtirnn onwd oe;ngligosuecnes itsh is ywh teh aybb is lmcypygchoei rghit no.w

)B eaeeDdrcs ylgongce otntnri-ccnaoe I not'd wkon eth lnycggoe nrtaccnioeotn oedrapmc ot an laudt piea,tnt ubt a edrcsaee ni ggloceyn coeirntatnocn lowdu atiendci lg/yucgnelcogose rlasee,e ihhcw wdoul ton eb a ipcehloymcgy a.estt )C dseacDere ynglgceo haystnse t-icyviat eadecdrse negcogly shnseayt tiyvaitc dseinctai egyner lobasm,atic nad ludwo dale to eghrhi suemr lscguoe .lelves D) dDeeaecrs mrsue unsinli necitctanno-or aereedscd uersm nuiisnl wodlu dlae to reihgh veslle of socugle in .uesmr )E rdIsneaec msrue -lesiniiuknl ogtwrh -focatr GIF sedo nto dinb ylanre sa wlle ot unsinil rrtpoesce as suniinl o,des and so would veah to eb in lmeeytexr ihgh tnirnnocaescot to ehva tshi fefc.et IFG si ssaaeicotd wtih itcomsa orghtw nad smleuc .vlenmoptede

neiPatt tihw raiteblla ealnr raytre urbist nda eirpyhetnnos llwi orf ures heav aivcitaotn of SAR tmessy adn eefrorthe nsereiac ni igna.nitsnoe

thuhglAo cpmceohmtoyoroah dan cuoetsnneq dleveeta iaetlnhmcscaoe can enscirae dolbo esuer,rsp psytmsmo rea cptailyyl sepodiic and rlaen sibrut ear nto kielly ot eb dea.hr levedatE lleves fo ronesnito nac aols sacue tnee,yirhnpos tbu ew oudwl loas ptxcee ot ese u;ighnlsf ,also htree is gionthn ni hte mset to enditaic itenpat is akgint SIsRS or hotsgniem lsee ttha oucdl rspesedipo hre to eelevdta evlsel fo tionsnro.e tdvlEeae velsle fo rtdohyi hmreoon udlco asol gevi aeptnti eeysth,iponnr btu we owdlu olsa xetepc rohet issng of roeyptirsiyhdhm ,(rsotemr tghiwe sols, .)t.ce

I aws a elttli oudcfesn if PEO olwdu be edeealtv -- if teehr is einstsos of renal rteaeisr as( idacnidte yb het b)urtis hte yndkeis could olsa detect htsi as ioapyxh nda apmr pu udntcriopo fo PE.O ,wHreevo I dened up gingo htwi tonenagsiin ceisn it sedeme eomr c"onr"eetc to me hatt ARS udolw eb .up Dsoe nyeano knwo wyh t'si not EO?P

drHa ot ese due ot roop rcipetu aut,liqy but adsbe on tawh I olcud ,ees ti seems lkei a uspnseanoot xtrpmhouneoa ot em b(deas on het lakc of nglu rkmiang no the felt mcerpado to teh rthig di)e.s

erfeorhe,T ecsin eth nglu is ,eddlfeat all uyo dolwu veah in eth elft sedi of eht open ,vciaty hchwi lduwo ekma het felt edis .shnrtpysroaene

hisT is a etqisuno ubtoa attepin p.rvaicy eTh tiaetpn heer si teh ldich. heT oryxp rfo the teiaptn is the ohmert nad tfah.re eThy tmsu wnok waths nrwo.g eSirts nda hetomr aer jstu ookol,lsyo nda rnapste yam nto wtna ot ltle them dustip( I ,knwo tub eerawhvt) so you snde meht out dna tneh llte the ertspan eth stuiio.tan

’Im nto eth tbse at teh lacltnioacsu of FFEC/C,I utb ylisbcala uoy rea nifgiuns a ioyrtcehnp nisoluto into the a.ilman ltyinI,ali tish is lla goign to og niot het lxeeaulrtlrca ,eacps as yan VI nniisfuo wlli od. Sncie it is iehghr hatn oosictin olnuo,ist wreta is igngo ot og rmfo het alrneclitrula epsac ot the rtxrleuellcaa eapsc to rty ot lacaben it ou,t so the eilrraatnclul acpes lilw aveh adseecrde evmulo dna racseidne myallsitoo csie(n ylno watre si ie,agvnl nmakgi ti rmoe tda.coernent)c

So uyo owkn orf ruse IFC uovlme si acdeersed adn asmiltloyo saeicdr,en nad teh ertarlcelulax lemvuo lliw eb resncia.ed I tikhn eth oloslitmya fo teh xutllalaerrec apces is eht rtkciy ptar dna eht tpar whree ybeam enesomo lsee anc hepl wtih eht anillutccoas but baasclyil ts’i cyeionpthr ghneuo that eth lsytliooam iwll llsit eb nesredi.ca

hYae rs,eu slet evgi teh uyg ohw wntsa to keep sih ikcd nirwgok adn eb aictevartt sdratow wmone isrentdeiaF and cepleomtyl rinu ihs ososrtntetee levsel and iveg ihm a ilpm ckdi, nam bboos, and eeaecdsrd efcrpnarome in strpos.

iSsetoemm teh NEBM lyaelr jsut meksa me kas yW?h

iapclTo loxmiidni dulow be awy eettrb tub on tyhe wotn tup tath sa a oicche

eTh cosstyil rrpesuse cfdnfireee wtnebee the flte vnerelict nad hte arota in tshi .pt si epttry nctn,ifgiasi hrWsaee in a anlrom rheat seoht stisoylc seserupsr dusolh eb sutj uatob uqea.l sTih sthin ta eth afct hatt eth felt vlnetecri ash ot tpu in otal of wokr to hups ruhghto hte iraoct ea.vvl hTta exrat seserrpu sego oitn gonipne teh vleva dan sedo tno apaepr ni het aa.rto

tPetina hsa tlyaicoephmy var,e as ednidecev yb ythceysrisrtoo, sor,slcingotauy dna ehcaedhsa m&;ap nisze.ids OEP is rcadedsee edu to ycorhtryestios. eaDedcser LAP ludow aedcitin MC,L not .VP

urmMurs nad u:eeansmrv s1t houthgt = who deso ti cahneg with .ldpaoer lAl mmuusrr ptexec H,MCO P,VM adn atilra xymamo iseervyt is drietlcy rlopirtoanop to anechg ni aprdloe (.ei. needracsi waseprloo=der umm,rur c..)te eecBuas of tsh,i DDx nca eb ewradron wdon ot OM,CH VP,M adn iartla ymmaox gitrh ywaa usabeec teh rmrumu wednosre iwht eaceddser erpdoal .i(e. gatdnisn pu) ehwn lla utb eeposcixtn iwth rep.ivom

ratilA oyaxmm = CCM mrpyair radccai urotm deu to aelfrroinopti fo evnicecnto utssei me;mehceyns a nedaudeputcl asms cdoneectn vai ktals ot mariut uetpms tath is dpsesdenu ni hte ltriaa bodol uvmelo dan moesv twhi eth moluve e.tneommv

nttrieenPoas: tiadr of )1 almtir avlev tibuorcotsn .(e.i sela,mai msptsoym of carcadi f,uearil ynpocs,e te.,c) )2 stmympos of msleiobm (.e.i fiacla dna tighr mar hsierismepa in t,nipe)ta nda )3 ltuaiotocsnitn ptsmoysm (e..i eevrf, egwiht lss,o spomystm eegbnsrlmi oivcntcnee ssiute ieesas,d acsebeu urmot esealers 6.L-)I hsrOte elcndui eciuoonrgl psomtmsy, apm"toedil-sur vavle iedse"sa rstcoluytuaa indsgfni .ie.( cliidsato ,mrrumu) nda laiatr mgreteenanl hhic(w dcuol ocrepsms yidgulrnen urststucre and uasec ytosspmm la.)os

otN yoln oeds gsntnida eecersad apo,edlr hciwh maens AL oevulm si lweor so sams si'tn sa dpeen"uds"s tbu reom ,elibom nsiandgt aols cnaeeissr hte arndwdow igatravtnoi oecf,r whihc dolwu ucenobtrti ot teh ourmt movign dwasrot teh aebs fo the aatrli eb,rcham inppl""opg on eth alrimt alvev ,felealst nda tplatnieloy txeenidng hrhuogt nda siaugcn a ncultofina ytpe fo rmalit esissnot ..(ei isnrnwoeg isclotadi )mruu.mr Tish eiovd easlnxip it yrlela ll:we =tn16Yhasbc;&phep:s.tsylc=t4aiu?mo/twI6m1LvwtgoV/.uww/

S,o orf oesm enaro,s sonaniertsumretrt si omeshntgi e'vI SLAAYW egduslrtg .h.iw.t pyroblab ubeeasc I awstn' hatutg it llwe os vener alyler lrdneae i,t usjt redanel ohuneg orf ereavhtw ae.mx I stju onufd itsh boo ughhrto CNBI nda sit TAACFS!ITN sI't ormf 0012 so hitmg be do,l btu it aws t.erag oYu cna ehascr hhrtuog teh bkoo nda find eht raephct.s I prteyt uhcm jstu wtne guhhtro lla fo hte rarneiemturotsnt pth.erca opmw.owbt./vnshs/wiilck9t9/h:B0/bK7no/1g.N.n

yM inma steau:mt aya-laekGtwa = amjor yaiexocttr mttosreunani.terr Two ytpes of preoestr)1 c: aobicomtep,rt sotm of icwhh rea priatcsenpy iG hciwh selad ot dacerdees DNAM creprote aitctivy nad risk fo xoycittxii,ecito or saoniptsctyp Gq pterrcseo htat elda ot ereasinc ,a+N K+, nda deacesdre uteatgmal uaessc lnaiiodazeorpt nad ansidcree +g+M lemencisdapt adn AMDN rctproee iyitvact adn rkis of cxioteyiit,cotx nda )2 oooniptcri cslnehan ilcngndiu DNMA dna tkA/iManeAaP ,aelnhscn hwcih lla waoll fisiecpconn intoca nui,flx btu nyol MNAD swoall +C+a ixfunl da(n nlyo in a legtoav dnnedpeet nmanre rteaf nceutiisff ialdzirtenooap sha apicsedld eth irnihibto M++g oin in hte nenha.lc)

GAAB dan lcyigne = bhiotiyinr etmrnueotistnas.rr 1 ) -AAGAB nad G-BACA = otoiprinco hcennsal thta eadl ot efxlu fo l,C- nda pseeitd hsit gcsnuia aooiarepztind,l the neornu iltsl tsasy eowlb nigrset apoei.tltn GA-BAA igdnnbi eist fro aerstuatri,bb ,estdsrio AGA,B nad pronixctio = iiesnd oper of lh.eacnn -AAABG ngdibni tsei fo naesbiezndpioez = udeisot fo oerp of hncea.nl )2 ilnyecG nanlhce is a ryev ailsmir l-C ufexl cl.nahen 3 ) -AGABB si a eatpmcoobirt nhnacel ahtt casaivett iG nedigal to aededercs MPcA which vatesacti lffexu +K alchnsen dan sthibiin C++a ifxlun annlecsh ilegdan ot oprhiapozalyrn.ite

ioiencBg imsena = natelciohsaecm pnamdoie ctidoo(anrnio of bydo eovmnmt,e r,ewdar i,avimotont ntnire,efcomr)e nereonherppiin ,lpee(s klswfau,ense etan,totni inegdef ,hoveraib nepripiehne wse(tol enarntniccoto ni SCN), splu rsitnoone pl,ees( wu,eeslsfkan ,esreondsip ,txaeniy e)auasn nda ihmtnaesi lasaur,(o tnatnteio, g,lyaerl sesuit aegdm,a nad mya uenfcinel bldoo ibarn wo.l)f so,vlOybui lal of this is in idditoan to carnreedig nrsurnmosteisinoa and lhgif,t rf,itgh and htgif snrpso.ee

PTA adn ohert upnries = citxryeato toa,nsrnimiss ascoeelr-ed iwht teohr -slolmcaeulelm arns.reurtenitomst endnioesA in'ts csaillslayc ndereicsod a anremtetntrrsoui sueabec it snit' etsrseeddora/le in aC++ etnedpdne nranem, btu dirvdee fmor ATP eerfbo ihvgna na xtcoyeriat t.oalptien

nicoletlAcyhe = jomar otunisarrmetretn evivodln in eruisnromtnsnaios avi scrmnaiu and tinonciic .erprcseot

pPedtei iteramnurnosrtste = yommnclo derelsae as pipteedpro elrgar rpsrecuosr atth ear vcelade yb cfisipec enszeym ttha eewr in hte smae urntintreortsema vsiceel nopu eesarel. Five tpsye = agtui/bnr iepetps,d oopiid ,isdpptee aryutipti pdstpi,e hthpoclamiay iaseglenr ornm,ehos dna eosth tno icf.ssdaiel samelxpE = roscuperr htta evisg esri to useanbtsc P iahpmopuspc(, x,rtoceeno adn GIT adn eseealrd frmo allsm ametiedr PSN C brisef taht istnrtam ainp dan trarutmpeee imitorf,aonn erulfowp ptiseoyvnh,e htinbidie yb doiopi ),seidpept unineirnko A, epeitneurdpo K, dan dnuioepterpe amgam, dan iiopdo dpsietpe udnlciign ptaln dliakolsa (ilek e,mrh)noip yihtstecn dopoii eetdvsr,vaii adn pornnehisd, drsy,iopnnh and anehesn.pilk nI enagrle doipoi pdeiteps are epsersntads i(.e. gelanasai mc,se)anhmi ndvivleo ni pxlmoec hobarsvei esxl(ua inratc,oatt sbsseaigvigiessvmu/er )ebohirvs,a dan plmdaeicit to(hugh otn t)vniideeif ni ycshiiapcrt siddrsreo.

vel,ralO easrustinnteromtr = pyte syte:p l-emoamlellucs nmirtesasrtt nda eet,rdnipseupo hrewe aesmomelculs-ll rainmstrstte rae stfaer dan idemtea dpiar npasctiy tonmisaisrns e(..i gonrenda SNS ghl/thfr/iiighffgtt kqiuc n)re,epsso herew as onpreusiedpet (oglan wiht cbgoolii sainme dna oesm mllsa elcloemu tre)tsranmtis rae woslre dan tdeemia ragda,lu eporlodgn aore.unnsoisnirtms

moSe ptecur:si //pidn/p_ouahpsruubsrid.peart_emtk/eeeefohmoritw:ctumitkeasntv.rte.nvww/_dlnho, 0-.tTds-aweue60ioiup2eRo0eg/ow4-aA-15r18mi66BlebldciB3t1/ne3e82arcs1u0/t2a/hsehsa3hp-brdgg6.f-1gprr-7cro-fttdi:/4gfcrs0aGerstAe4wpn/9ebbirlPfnpa/a3, and a4apb0o&ei2s;beg/1g7psxee-unr0/#nw85/td-=.x1acb3g1/_.fele:ehm-w-d6itga-1aaUw6l.f-t2at5bd=dgrin-hiabl93h-eesw/frl/dft

ynA etmi uoy see xidfe dewi tngiiptls of 2S, msash ASD.

This apttnie peensstr htwi a laslm ecll rmoaaincc ciwhh si yevr oncmom for apra osncplteia dnssme.roy In hist asce the nacerc si sgcanui I.AHDS lieeDlccoeymn is a yenialtrtcec itotnaiicb ttah si lsao edus ot rtate DSIHA

tesBggi cuel was tath heret was no iemt ermfa igevn. hr,eeoerTf htis emses ot be a ce"lsi in e"tim ys,dut ihchw lsein pu hiwt osrcs ctaoesnli dsyut.

Teh lyon nentfcoii no tath itsl hatt uoy luwdo neev senrec na toiswereh laethyh iaareppgn iuvdiaindl si eBHp. heT etsohr I ulowd thkni oyu loyn hckce fi eht paietnt sha a stipoentaern htta ksmea uoy tpcsuse mth,e klei BEV if hyet dah sgnis fo n,oom or SRV if hety dah isaorprrtey opyss.mtm At ttah ,pnoti he'etyr on enlrgo ecigsernn st,ste tbu moer oagisdnict nseo.

He ash tahre uferlia iwchh lsaed to a eeradecs ni nlrae dobol lwfo dna alenrrep ozmae.ita In lpnerera tme,oaaiz r:CBNU traoi si =g&;t ;02 ovacAniitt fo het SARA eytssm ude ot hte parlnree aimaeozt aemsn atth het escp vrga is ihgh at 210.5 dan he si giodhnl tono dmuosi so nrryuia omdisu will eb olw 20(,t;l& FEaN ).1;&l%t

sThi nittpea is pirgnpti s.ball tBeert do a rudg secenr chiwh eesms ob.voius