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Retired NBME 23 Answers

nbme23/Block 3/Question#10 (reveal difficulty score)
An investigator is studying two drugs, Drugs ...
Area under the curve ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: pharm_calc

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 +10  upvote downvote
submitted by โˆ—mcl(671)
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This is a nice quick refresher of what AUC is.

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 +6  upvote downvote
submitted by rossiememe(6)
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DOSE x F = AUC x CL

(F= Bioavailability)

If dose is constant and F is increased for Drug X then AUC would increase.

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melanoma  and the cl? +2
cassdawg  Clearance is independent of bioavailability as it is determined by the rate of elimination (affected by liver and kidney "clearance" of the drug, not the "absorbability" that is essentially bioavailability) +1



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