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NBME 23 Answers

nbme23/Block 2/Question#15

A child with septicemia has an antibiotic clearance ...

28.8

A child with septicemia has an antibiotic clearance ...

28.8

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lispectedwumbologist
That's so infuriating I stared at this question for 20 minutes thinking I did something wrong
+14

seagull
lol..my math never worked either. I also just chose the closest number. also, screw this question author for doing that.
+2

yotsubato
Why the FUCK did they not just give us a clearance of 0.1 if they're going to fuckin round it anyways...
+4

cr
in ur maths, why did u put 24h/1day and not 1day/24h? if the given Cl was 0.09L/hr/kg. I know it just is a math question, but i´d appreciate if someone could explain it.
+

hyperfukus
magic math!!!!! how TF r we supposed to know when they round and when they don't like wtf im so pissed someone please tell me step isn't like this...with such precise decimal answers and a calculator fxn you would assume they wanted an actual answer!
+

Hey can someone please explain this! I am not sure how to do the math, I keep getting tripped up.

mousie
Equation is Maintenance dose = (concentration at steady state) * (Clearance)
if you convert all the units to what it wanted them in (mg/kg/day) you'll get 25.92 like weird-in said above
I didn't think to round 0.09 to 0.1 of course so I guessed 2.5 assuming I must have done a conversion wrong and was off by a tenth .... BOO bad Q
+4

submitted by wired-in(23), 2019-05-30T03:40:03Z

Maintenance dose formula is (Css

Cltau)/F where Css is steady-state target plasma conc. of drug, Cl is clearance, tau is dosage interval & F is bioavailability.Neither dosage interval nor bioavailability is given, so ignoring those & plugging in the numbers (careful to convert units to mg/kg/day): (12 ug/mL * 1 mg/1000 ug) * (0.09 L/hr/kg * 1000 mL/1 L * 24 hr/1 day) = 25.92 mg/kg/day

...which isn't any of the answer choices listed. They must have rounded 0.09 L/hr/kg to 0.1 L/hr/kg, and doing so gives exactly 28.8 mg/kg/day (choice C)