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NBME 23 Answers

nbme23/Block 1/Question#19 (39.1 difficulty score)
Unlike the DNA polymerases found in ...
Mistakes in transcription are not transmitted to progenyπŸ”
tags: biochem genetics 

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 +8 
submitted by krewfoo99(88),
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So iaslyblca athw siht is snayig htta NDA liwl be mnttdsariet to the rygenpo otn R.ANo S DAN lwil lcpeeirta ni eht G2 paehs adn tnrasref of AND itaarelm to ogynpre lwil ccuor in the M phse.a ehT ARN yma be utamdte dan migank tiveeedfc tdpcorsu, tbu thsi lliw tno nitatsmr toin teh pnrygoe, htsu not afigntcfe csseepi auvrislv daebs no RAN aomtisnut.

bk2458  makes sense!! +  
almondbreeze  good work +1  
tyrionwill  the question asks the reason of no impact on its survival. if a protein translated from a wrong mRNA loses its function, how can we say the bacteria will still survive well? if there is always fatal error happened during mRNA transcription, and always leading to fatal dysfunctional protein, how can the bacteria and its progeny still survive? so the point will be whether the fatal errors will always happen during transcription? I dont know... +  
tyrionwill  actually FA and NBME seem to have made a wrong statement that RNA polymerase has no proofreading function. RNA polymerase has more fidelity to DNA than DNA polymerase by 2 ways: 1) highly selection of correct nucleotide, and 2) proofreading. (Jasmin F Sydow and Patrick Cramer, RNA polymerase fidelity and transcriptional proofreading: https://pure.mpg.de/rest/items/item_1940413/component/file_1940417/content) however, if survival of the species refers only to the reproduction of progeny, mRNA mutation has nothing with the progeny. +1  



 +4 
submitted by keycompany(295),
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hiTs tuqnieos si de.dsisgui atWh htye era ellayr snikga is "hwat si eht oesl ttmdeiarnne fo epiessc airvvlus?" ehT noyl renwsa is eht abitiyl to por.receta ceBsuae DAN soalmeyPer hsa ofiarorn-gped ttcai,vyi gyernop llwi eb teufcenfda by NAR slaPymosree klca of forade-niogpr vic.yiatt

ls3076  the phrasing of this explanation doesnt make sense to me. +4  
ls3076  oh wait sorry i just read it again. So instead of proofreading how are errors handled with RNA? +  
thomasburton  Think the point is basically although errors with RNA polymerase make make the bacterium not very good at infecting or killing or whatever it does not affect replication as it is not used during replication! +5  
almondbreeze  common sense asked in a very very convoluted way.. +  



 +1 
submitted by seagull(1393),
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in.rwet./g/npdtgsepaPoor/iiohgli)(if_iakiowrd:b/yeko

Here is a lttile bit no roH.peaprdioneofg it elhsp

jcmed  I'm dropping out +1  
drzed  This question doesn't have to do with proof reading, even though it is mentioned. It is just saying this: you can make all the misfolded proteins you want (e.g. proofreading can be messed up), but it has no relevance to the PROGENY. Why? The progeny of a cell is dependent on DNA replication only--so long as your DNA is perfectly replicated, the progeny will come out perfect. You don't need to worry about RNA to make DNA (unless you're HIV, of course!) +5