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Retired NBME 23 Answers

nbme23/Block 2/Question#45 (reveal difficulty score)
A 61-year-old man is prescribed fluoxetine ...
Raphe nuclei ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: mnemonics

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submitted by โˆ—sugaplum(487)
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This is ridiculous but I could never keep these straight so meet my family:
Achey grandpa Meynert
Dope cousin VT with a side Ho* (who's names are just initials) SNc
Uncle and aunt Raphe and sara Cousin Gabby always screaming Na-Na-Na
norepi reminds me of the color blue, so locus ceruleus

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paulkarr  LOL. Achey Granpa Meynert. I'm gonna steal this from you. +
abhishek021196  Achey grandpa Meynert = ACh / Basal Nucleus of Meynert Dope Cousin VT = Dopamine / Ventral tegmentum, SNc Uncle and aunt Raphe and Sara = Serotonin / Raphe nuclei(medulla, pons) Cousin Gabby always screaming NA-NA-NA = GABA / Nucleus Accumbens Norepi = Locus ceruleus. +2
llamastep1  Amazing +
mnemonicsfordayz  ACHey GRANDPA MEYNERT TREMBLES in the BASEment; DOPE cousin VT SNaCks DOWNstairs by the kitchen TAP; NANA GABBY ROCKS and ANXIOUSLY cooes...; "NENENENE... NENENENE...NENENE...NENE" to CRYING BLUE-eyed baby ELSIE; aunt SERO and uncle RAPHE DULLY PARK in the DOWNpour. CAPS = relevant info, lowercase = irrelevant. Includes diseases: DOWN, ANXIOUSLY, CRYING, DOWN = anxiety/depression; TREMBLES, TAP, ROCKS, PARK = movement disorder; GRANDPA = Alzheimer's. Note: ELSIE = LC = Locus ceruleus +
mnemonicsfordayz  The extended "NENE" series is just for humor - shorten if you like ;) Also, ANXIOUSLY applies to both NTs in that sentence: GABA and NE. +
castlblack  I use AChoo meynose +1
faus305  I almost didn't even look at this review but then I thought "maybe someone has a cool mnemonic." and would you look at this. +1
chaosawaits  My Cousin Vitty! +1
madamestep  Sister Nora in a blue sweater Also if you've seen the devil wears Prada there's a whole fun scene where Meryl Streep destroys Anne Hathaway for not caring about fashion in her cerulean sweater. So that scene reminds me of how stressed (NE) Anne must be in her cerulean sweater. +
sd22  honestly after this exam i will never be able to take my docs seriously. All i see now are the dumbass mnemonics running through their heads. +



 +2  upvote downvote
submitted by โˆ—dr.xx(176)
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SSRIs produce a sustained increase in extracellular 5-HT in the dorsal raphe (DR), and this leads to autoinhibition of serotonergic neurons.

http://jgp.rupress.org/content/145/4/257

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davidw  Pg 483 in firstaid has a good table of where the neurotransmitters work +6



 +2  upvote downvote
submitted by โˆ—osgoodschlatter10(41)
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Serotonin is synthesised at the Raphe nucles. Hence, Fluoxetine which is and SSRI will prevent Serotonin synthesis since it maintains a high level of serotonin in the synapse.

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 +0  upvote downvote
submitted by dennydrash(1)
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I always remember locus caeruleus as Marcus Aurelius (if anyone has seen the movie Gladiator) its about action and being hopped on up Nor epi would recommend

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submitted by โˆ—llpierso(3)
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I remember Raphe by thinking of Raffi the musician, best known for his '90s classics, Bananaphone and Baby Beluga. Raffi ("Raphe") makes you happy (like SSRIs).

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