SSRIs produce a sustained increase in extracellular 5-HT in the dorsal raphe (DR), and this leads to autoinhibition of serotonergic neurons.
http://jgp.rupress.org/content/145/4/257
Serotonin is synthesised at the Raphe nucles. Hence, Fluoxetine which is and SSRI will prevent Serotonin synthesis since it maintains a high level of serotonin in the synapse.
I always remember locus caeruleus as Marcus Aurelius (if anyone has seen the movie Gladiator) its about action and being hopped on up Nor epi would recommend
I remember Raphe by thinking of Raffi the musician, best known for his '90s classics, Bananaphone and Baby Beluga. Raffi ("Raphe") makes you happy (like SSRIs).
submitted by โsugaplum(487)
This is ridiculous but I could never keep these straight so meet my family:
Achey grandpa Meynert
Dope cousin VT with a side Ho* (who's names are just initials) SNc
Uncle and aunt Raphe and sara Cousin Gabby always screaming Na-Na-Na
norepi reminds me of the color blue, so locus ceruleus