NBME 23 It increases plasma concentrations of other PIs also metabolized by cytochrome P450 (NBME Answers)

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NBME Answer Explanations

NBME 23 Answers

nbme23/Block 1/Question#8 (reveal difficulty score)
A 30-year-old man with HIV infection comes to ...
It increases plasma concentrations of other PIs also metabolized by cytochrome P450 🔍 / 📺 / 🌳 / 📖
tags: biochem p450 pharm drug_interactions

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+10 upvote downvote
submitted by ∗step420(32)

Ritonavir inhibits CYP450! So you can use it to boost the concentration of the other Protease inhibitors by preventing their metabolism by CYP450!

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mousie who knew +7

sympathetikey Right on (thanks sketchy) +10

mguan1993 MAGIC RACKS is a good mnemonic ive heard for 450 inhibitors (macrolides, amiodarone, grapefruit, cimetidine, RITONAVIR, alcohol (chronic), cipro, ketoconazole, sulfa +6

criovoly "CRACK AMIGOS" Cimetidine Ritonavir Amiodarone Ciprofloxacion Ketoconazole Acute alcoholism Macrolides Isoniasid Grapefruit juice Omeprazole Sulfonamides +7

drzed Macrolides EXCEPT azithromycin -- they like to trick you with that one. +3

steatorrhea chronic alcohol induces 450, acute alcohol inhibits 450 +3

an1 This was added in FA inhibitors list last year I think. SICKFACES.COM when i AM Really drinking Grapefruit juice +

+0 upvote downvote
submitted by kungfupanda(5)

Check Pg 203 in FA . its clearly given. but i choose the wrong answer!

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