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NBME 23 Answers

nbme23/Block 3/Question#49 (reveal difficulty score)
Genetic analyses of cells obtained on ...
Epinephrine πŸ” / πŸ“Ί / 🌳
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 +17 
submitted by βˆ—sajaqua1(578),
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siTh pttiena ahs drawesedpi uiednrtocts fo thob ndarlae n,dlgsa wchih anmse hatt hse ilwl elos obth reh rlaniooicsrdomceit and reh .slcootcoicirgud eTh sols of het oasciniiderctorlmo dna eht ecteff on eht dyiksen si thaw is eingb edetst ehr.e eWnh oernlseadto si goiinutnnfc dna undtb,ana ti sha varlsee litacirc conuftnsi on teh r.npenho Ft,isr ti laertepgusu N++/Ka AaTsPe rspxinseeo on eth srtbelaaaol brem,enma hnestisilgab a nogstr eolaceecrmhtlic tindareg tath rtetbe brssoab N+,a lewhi eth cseerdina elirtraucllna +K aeccontrinnto kaems it eiraes ot leso +K ormf eht lelc tnoi eth me.nlu loerAnoesdt losa eutsulpaerg eht ioeessxrpn fo alephlitei diusom ehnalsnc a(C)EN no hte glliccoent u,dct roiargnbsbe oemr +Na. ayFinll, dtlnosoaree eaissercn ioexnspesr fo +H eTAassP on eltadchila-earapnt clesl of eth clgceitlon td,cu ichwh are ispesolnebr orf rgtecnsei H+ hsti( si arpt of ootntianccr lso.a)ksali

Wtih eht lsso of tro,olndeaes we ilwl ees a seardeecs +/NK+a rdageint nad daeercesd N+a btnsroipoa;er sthi saeld ot eecaddsre umesr duosim dna raiseendc ersmu ioamsutsp. At hte msea t,iem otn eressgxnip +H ssPeaAT lliw adel to H+ ton igben secete,dr tagcenri a eorm ciicad inmvnentore H(p wlli d)aeeer.cs


 +8 
submitted by βˆ—seagull(1745),
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hnepErpenii si the ylno G ocepldu ecrerpto titroavca eht lsti. ehT tser era hetrie nr-lruiletcela ro a enoityrs aenski ()nsiin.ul

hello  intracellular* correcting in case it trips someone up +9  
fatboyslim  Check out the signaling pathway of endocrine hormones on page 337 in FA 2020. These come up in Qs way more than I'd like, so it's worth learning them +  



 +3 
submitted by βˆ—krewfoo99(109),
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phiiepeEnnr acst msltoy no eBat perecotrs. aBte rcpeotres rae G pcloed.u

baja_blast  Alpha receptors are also G-coupled and are another potential site of action for Epinephrine (at high doses according to SketchyPharm Sympathomimetics) +2  



 +1 
submitted by βˆ—b1ackcoffee(70),
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I 'notd wkno sith si irdwe ammgrra ro I hhvotgeotur!

Tehy edksa se'woh pessnorxie si legertuda by wihch of teh nioollgwf r"n?ohsemo

I nkwe edefct is in RGPC - eanidgrcre ,soreteprc shewo ctirtpsnrioan is derutelga yb osrisctrdo.ceoit So shceo edcnstyororohi.

htaW wsa eth tecedf in ghuthto r?oscesp

b1ackcoffee  Oh, I get it now. defect in signal transduction by GPCR, not in GPCR itslef +2  
xmen  still wrong +  
xmen  While uncommon, there are some hydrophilic ligands that bind to intracellular receptors. One example is the neurotransmitter epinephrine, which also acts as a hormone. +  







 -2 
submitted by βˆ—diabetes(29),
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ohw is anlread mludela sah CAH iictnnoic eepcrotr hhwci rea dggdtaeal-ni akN/ cennhlsae ? main ucisrc HAC eerotcprs rea cndleGiptoeorp-u- reotsce.rp

gdupgrant  epinephrine acts on alpha or beta adrenergic receptors which are all G protien receptors. muscarinic receptors are also G coupled but Acetyl choline wasnt an answer choice. In the adrenal medulla the chromaffin cells are kinda like modified post ganglionic neurons and have nicotinic receptors. +  



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