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NBME 23 Answers

nbme23/Block 3/Question#49 (reveal difficulty score)
Genetic analyses of cells obtained on ...
Epinephrine πŸ” / πŸ“Ί / 🌳

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submitted by βˆ—sajaqua1(578),
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submitted by βˆ—seagull(1745),
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hnepErpenii si the ylno G ocepldu ecrerpto titroavca eht lsti. ehT tser era hetrie nr-lruiletcela ro a enoityrs aenski ()nsiin.ul

hello  intracellular* correcting in case it trips someone up +9  
fatboyslim  Check out the signaling pathway of endocrine hormones on page 337 in FA 2020. These come up in Qs way more than I'd like, so it's worth learning them +  

submitted by βˆ—krewfoo99(109),
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phiiepeEnnr acst msltoy no eBat perecotrs. aBte rcpeotres rae G pcloed.u

baja_blast  Alpha receptors are also G-coupled and are another potential site of action for Epinephrine (at high doses according to SketchyPharm Sympathomimetics) +2  

submitted by βˆ—b1ackcoffee(70),
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I 'notd wkno sith si irdwe ammgrra ro I hhvotgeotur!

Tehy edksa se'woh pessnorxie si legertuda by wihch of teh nioollgwf r"n?ohsemo

I nkwe edefct is in RGPC - eanidgrcre ,soreteprc shewo ctirtpsnrioan is derutelga yb osrisctrdo.ceoit So shceo edcnstyororohi.

htaW wsa eth tecedf in ghuthto r?oscesp

b1ackcoffee  Oh, I get it now. defect in signal transduction by GPCR, not in GPCR itslef +2  
xmen  still wrong +  
xmen  While uncommon, there are some hydrophilic ligands that bind to intracellular receptors. One example is the neurotransmitter epinephrine, which also acts as a hormone. +  

submitted by βˆ—diabetes(29),
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ohw is anlread mludela sah CAH iictnnoic eepcrotr hhwci rea dggdtaeal-ni akN/ cennhlsae ? main ucisrc HAC eerotcprs rea cndleGiptoeorp-u- reotsce.rp

gdupgrant  epinephrine acts on alpha or beta adrenergic receptors which are all G protien receptors. muscarinic receptors are also G coupled but Acetyl choline wasnt an answer choice. In the adrenal medulla the chromaffin cells are kinda like modified post ganglionic neurons and have nicotinic receptors. +  

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