need help with your account or subscription? click here to email us (or see the contact page)
join telegramNEW! discord
jump to exam page:
search for anything ⋅ score predictor (โ€œpredict me!โ€)
NBME 23 Answers

nbme23/Block 2/Question#29 (reveal difficulty score)
Which of the following pairs of drugs ...
Lomustine and cyclophosphamide ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: pharm Immuno

 Login (or register) to see more

 +7  upvote downvote
submitted by โˆ—gabeb71(51)

Lomustine ia an alkylating nitrosourea compound used in chemotherapy. Alkylating agents crosslink DNA.

Cyclophosphamide metabolizes into a phosphoramide mustard. Phosphoramide mustard forms DNA crosslinks both between and within DNA strands

Cholchicine and Vinblastine work on microtubules

Methotrexate and 5-FU both work on purine metabolism.

Cytosine arabinoside interferes with the synthesis of DNA. Its mode of action is due to its rapid conversion into cytosine arabinoside triphosphate, which damages DNA when the cell cycle holds in the S phase (synthesis of DNA). Rapidly dividing cells, which require DNA replication for mitosis, are therefore most affected.

 Login (or register) to see more
smc213  To clarify Methotrexate (inhibits dihydrofolate reductase) and 5-FU (inhibits thymidylate synthase) in the Pyrimidine synthesis pathway. 6-MP inhibits Glutamine PRPP amidotransferase in the PURINE synthesis pathway +7

 +4  upvote downvote
submitted by โˆ—thotcandy(129)

TIL cytosine arabinoside is another name for cytarabine (pyrimidine analog)

 Login (or register) to see more

Must-See Comments from nbme23

ferrero on Precapillary resistance
yotsubato on 99%
sne on Triglyceride
sajaqua1 on Area labeled โ€˜Dโ€™ (Spinothalamic tract, right)
hayayah on Iris
stinkysulfaeggs on Hypoglycemia
soph on Peak inspiratory pressure (alveolar): ...
seagull on Area labeled โ€˜Cโ€™ (Cranial nerve 8: ...
water on Dietary change
wired-in on 28.8
beeip on Binding of permeable ligand to nuclear ...
thomasalterman on Hypoglycemia
seagull on Decreased sodium bicarbonate reabsorption in ...
yotsubato on Inhibition of the cytochrome P450-dependent ...

search for anything NEW!