fancy upgrades later tonight!
🤖 site will be down for an hour or so.
❤️the webmaster --9.22.2019, 12:35am
to snoo-finity ... and beyond!
NBME 23 Answers
An investigator is studying the adverse effects of ...
Presentation of antigens to CD8+ T lymphocytes
Another way to approach it is to think about MHC class I processing. Basically, if you inhibit the proteasome, peptides will not be generated and nothing is available to be loaded onto MHC I (remember MHC I has to be loaded before it's transported to the cell surface). Cells that don't express MHC I get killed by the natural killers.
"In conclusion, we have demonstrated that the proteasome inhibitor bortezomib down-regulates class I and enhances the sensitivity of myeloma to NK cell–mediated lysis" from the conclusion of the NIH paper