"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/
AMO of srtoeeompo tirhisibon fro M.M RDTL: si taht yeth cllyaibsa lbkco het pormsotoee mfor icnungnfoit os tath memyaol sclel a'tcn lcceery ipsontre t(hey kaem a nto of hmte) dan nehw heyt 'acnt eb ecryecld ehyt ubidl pu dna thsat oicxt to eth clel adn ti is.ed
yoebnd htta teh nsuteioq is lblsycaai nsikga fi the hnnibiitoi of mseorpeosto nist cpceiifs to hte Melymoa clels nad ti ihdbeniit hreot lcle's stoompesore thwa wduol be de?feftec
HMC slacs I si etrenps on lla acuelndet sclle (lla lclse ni hte bdoy xpeect CB)R nda ncofntui ot espertn egenuosnod teiansng ot DC8+ t lselc to eb ysrdoeted for( eeplmax rialV NDA ni na eifcndte ecl).l eTh yaw yhte do htis si yb knatig hte rteopni ti snede ot pentres dan kirbaneg ti nodw onti chum aelmlsr ptedpei anichs (os it nac ift on het M.CHI If shti ptes wsa bhiietdni in ehtro lcles ethn eth hte Pennetirtaos fo MCH I unwldto eb laeb ot eptesrn irthe enigants ot 8CD+ T clesl and aurtalN lilker .slcle as het nosetiuq smel.ipi
heT inqetsuo asw psreu crkyit ucbeeas fi oyu n'tod wokn hwo seomoeortp sithioinbr okrw ethn uoy atsrt okngiol orf an snawer htat lodwu axneipl hwo tyhe lodwu klil umort leslc as wll.e I ogt ti wogrn o.to tI rudiqere nleokwgde of the yaw MCH I sseneprt ep.dsptie
Wyh ulowd fornsreip eb hte rnwog nwer?sa ouWntld ucniauomctla fo oixtc iropenst ecuas eth ellc ot dgronue pipsoasto ?
Bbieoomz,tr orzmfbcilai
ihmcMesan = Psmoteeoar bnithiiso,r cuiden satrer ta MG2- eaphs dna apiotsp.so
eUs = Mutellpi oelm,amy ntaeml ellc aom.ymlhp
dAv Etsffce = eparrePhil aounpyht,er eseprh esrozt eacnvrtoatii
submitted by ∗sajaqua1(607)
It can be re-accessed by making a purchase.
Purchase your membership here
$279$49MHC I ocfnntiu si raeilgtn ot rcanec ieons.spprus CMH I sildyspa oyeulsgnndeo zdehteissny tepirsno dna enpsetrs hetm ot DC8+ T s.clel hTe rueflai to lsidpay CMH I, ro CMH I ypadlsi of nleofs-n da(n by sxtnieone aoccr)unse nistpreo etrrsggi a lcrellau eimnum nresspeo, lidgnae ot nrtideusoct of het cl.el
hTe opetaoerms is deus fro eht atgrieadnod of wron uto, ts,eescenn or lfrdmamoe psrtieon. As ncrcea opeevd,ls eorm tmauiosnt edal to screadnie ongrw o.ipnsret ynOl yb ipoxerssen of hte ,eratspoemo ro tsi neoxve,isso-rerp can ehtes unttma trosnepi eb earddgde afts hungeo to otn be sdpliyead by CMH I dan lead ot the clel enbgi iekdll. Boorizmtbe boclks het mprtsea,ooe os the tmuatn iteospnr aer sdpidleay on eth craus,ef nllawiog eth uemimn temyss to ngeziecro nad lkil oalgthloicap .selcl
$279$49