"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/
MOA of smooerotep nhtibroisi rof .MM RLD:T is atth htey licaybsla obckl teh otoreospem frmo otnucinnifg os thta lyammoe csell cn'at ceyelrc torpeins ye(ht keam a ton fo h)etm nad hewn tyhe tnca' be cdrcleey ythe ldiub pu nad thast tocxi ot eht lecl dan it ide.s
ndboey that the nseoiutq si asaicybll inaksg if hte ihonitnbii of seootorsmpe istn ccispeif ot eth emlaMyo clles nad ti eniiihbdt etroh lc'sle roetsmsepoo wtha udowl eb eteff?edc
MHC scsal I si ptneres on all autdeecnl sclel a(ll llcse ni het odyb cpteex RC)B adn tifunonc to pesrten ngnduseoeo ntneagsi to 8D+C t slcle ot eb trdoeysde ro(f laexepm alriV AND in an efidcetn el)lc. The way heyt od thsi si yb itngka het tpinoer it nsdee ot eretnsp dan nagebkri it nwod iont uhcm slalmre edeitpp hsacin os( it nac tfi on the H.MCI If htsi pets swa deihibnti ni ehtor lescl hetn hte teh arPnneseiott of MCH I ondltwu eb able to ntesper rihte nistgaen to DC8+ T llces nda lurtaNa likler lclse. as the nqsoieut m.eislip
The qitesoun saw usper itrykc cebusea if oyu 'ndto ownk who ooermepots rsbinotihi kwor hten ouy tarst ilknoog rof an ranews ttah wldou epalxni hwo yteh dwolu ilkl tmuor lscle as le.lw I tog ti nowrg o.to It erdreqiu nwoegekld fo teh awy CMH I pssreent epesi.dpt
yWh uodwl poesirrfn eb het rwgon res?naw utolnWd ocumtniaaluc of oxcit tpnsireo saecu hte lelc ot renugdo pisotpoas ?
ioBb,merozt rzifmiblaoc
scinaeMmh = Pemtorosae soi,hbrntii edinuc etarsr at -2GM ahspe adn posptoai.s
seU = Mteulpil lomyeam, aeltmn clle hlomymp.a
dvA fEsctef = aPlperheir het,urnaoyp hrpese eozstr vnicteiorata
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$379$49HCM I tuficonn is glieatrn to ccearn iprssupnse.o MCH I adilsspy gdeonsunoeyl ietsnyezdhs oestpnir and espenrts hmte to D+8C T llcs.e eTh fuailer ot pldaisy MCH I, or MHC I ladsiyp fo nles-ofn n(ad yb ntnsoexei c)esounrca isnerpto stgiregr a rlulclae imnmue onsr,epse eldaign ot edotrsiutcn of het lce.l
The rpmoeosaet is usde ofr hte idetoardagn of norw o,tu ntsnsee,ce ro dmmelrafo tprinso.e sA ccraen elo,edpvs roem oitmsuatn lead to srinedaec rowng ipo.enstr ylnO yb reisxnsoep fo hte ,sreaptoome or sti xrnio-esso,eerpv can thees tumtan nirpstoe be geedrdad fast ougenh to otn be sdlyiaped yb CMH I dan lead ot eth cell begni .ldiekl rozbeimBto koblcs hte eepoor,tsma so the mattun orsepnti ear sdleiydpa no the r,cefsau glnowlai eht mimeun tsseym to nicegzero nda ilkl allhoigcptoa .lelsc
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