"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/
OAM of moooeetprs ronbthiisi fro .MM L:RTD si that tyeh lybcasali bokcl hte oesorptmeo mfro nncitonfgiu os thta mymlaeo celsl 'nact cryecel sopteirn hyt(e meka a ont fo )tmhe nda wenh thye nt'ac eb ycecdlre yeht iubld pu and tthas oitxc ot het llec nad ti de.is
oenbdy htat the iqsnuote si isyllabac angkis if hte tinbnoiiih of pretoossemo stin cifpseic ot hte oeyMaml llcse dan ti intihbied toehr sc'lle etemsorposo wtha lduwo be cfeeftde?
MHC cssal I si spenert on all neledtauc elcsl lal( sclle ni eht obdy tecxpe CB)R adn cnotiufn ot trsneep gsnoednueo ntgesnia ot DC8+ t eclsl to be dyrtdesoe fro( lemapxe rVial DAN ni an eefndcit clle.) heT ayw ythe od isht is yb atgkin eht reiptno ti endse to snetper nda iankgerb it dnwo tion much rlsaeml itpeedp nischa so( it anc itf no eht C.HIM If thsi spte wsa intdbiehi ni hreot csell tneh teh the eatronsenPit fo MHC I tdwlonu eb able ot netpesr rithe eiagnnst ot D8+C T elslc and utlaNar lreikl llecs. as eth iestuqon ielpism.
eTh uqtonsie swa rupse crtyik abueces fi uyo odnt' nwko how ompteseoor rnihiotsbi orwk enht oyu ttsra goinolk fro an asnwre hatt uwdol xipalne hwo yteh wudlo klli outrm llces sa .wlel I tog ti rwogn o.ot It deiruerq kdgwnoeel of hte wya MHC I resnpste ptedpsi.e
hWy dlowu osiernpfr eb teh orwgn wnsa?er nuWdotl aolctaciumun fo oxtic isoretpn suace hte ecll ot eroudng spspotioa ?
bBe,orzmtio fzmbocairli
Mnimhasec = rsPeoeoatm osbitiinh,r deicnu srrate at G2M- epash dan .ptssaopoi
seU = pelilMut lo,emmay amlten lelc aomyhlp.m
vAd ceffEst = iePlpaerrh htrpya,euon rspeeh etorsz cravintiteoa
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$279$49HMC I nuoniftc is ngalrtie ot cnacre ssrponu.sipe MCH I yipsdsla eondgsyoulne etzsshdenyi etsopnir dan eserstpn ehmt ot DC+8 T .lscle heT ielaurf ot laipsdy HCM I, or MCH I lyipads of eslnofn- a(dn by ieonnetxs eu)cnrasco oinsetrp eigtrrgs a cralellu miemnu rn,speseo ildegan to snctoridtue of het lecl.
The tooepamrse is ueds rof eht ntoaadgider fo worn ou,t ne,steensc or mmfrealdo .eorsptni sA reaccn ovedpse,l remo mtiutsano dael to iasdercen grown s.nrpetoi ynOl yb esoprnexis fo the eoarteposm, ro sti ve-niesrseoorp,x nca tshee tnautm onpitser eb eagdderd astf hegoun to tno eb eiylsdpda by MHC I dan ldea to eth ecll bgnei ldki.le teBobrziom bclkso teh era,msoepot so the anmtut irposent aer plddseiay no hte saeuf,rc owainllg eht emnmui yetssm ot gcnerezio dan lkli pgicloaaloth e.lcls
$279$49