NBME 23 Presentation of antigens to CD8+ T lymphocytes (NBME Answers)

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Retired NBME 23 Answers

nbme23/Block 1/Question#22 (reveal difficulty score)
An investigator is studying the adverse ...
Presentation of antigens to CD8+ T lymphocytes 🔍 / 📺 / 🌳 / 📖
tags: immuno repeat

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submitted by ∗sajaqua1(607)

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HCM I nitnofuc si nelitgar ot cencra usopsnspei.r HMC I ilsapdsy dngoeyuelons eenissdhyzt nepotsir adn snrtespe mteh to C+D8 T .eclls hTe raeflui to adlypsi MCH ,I or HCM I ylaipds of -efsonnl nd(a by itsnoxnee cncuao)sre roniptes grtrgeis a lrlaluec miumne sn,psoree igenald to irdonttuces of eht .lecl

Teh toomapsree is used rfo eth nrtdgaeaido fo orwn ou,t nsc,eeents ro fdmrelmoa .sotrinpe sA neracc lpeods,ve ermo snttumaio eadl to cidreneas wgonr snpoiret. nOly yb pseneirxso fo teh om,eapotrse ro sit xpoeino-sreer,vs anc etseh ntmuat sieptnor be adregedd fsta ughneo to ton eb syaddepil yb CHM I and eadl ot hte llce binge e.ldilk btmzeirooB kcbols het poearstoem, so eht tuatmn noristpe aer dalyepisd no het sufra,ce lwogalni eht nemium msyset to ineozgcre dan llki gaohillpctoa esl.cl

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catch-22 Arhetno ywa ot roapaphc ti is to tnhki utabo MHC scsla I nigrocs.pes Baiyslal,c if you nbithii eth rpaeooest,m sedieppt lliw ton eb eagertden nda nhitnog si ivbeallaa to be dleoad ntoo CHM I erbremme( CMH I hsa ot be eadldo ebefor 'sit strerdnopat to eht lecl ).cruesaf selCl thta dtn'o sxesrep HCM I tge ikldel yb teh tlaaunr k lisr.elPin6b/mr1wh3t22t.n/neh/:scc/w7v./wsoamipl..4gclM/pCti +32

kai "nI l,csinouonc ew evah oterdmatdsne that the eseapmorto htrbiioin rooitbezmb osdatl-urgwnee sacls I and eenchsan teh tniitivesys of omlyaem ot NK emei–lctaedld sils"y ofrm hte oliunscnco fo hte HNI rppea +6

maddy1994 oheatnr miheacsmn si yb oiglbnck ooetromeps u veen recaedes orgindate fo rpocatppoiot sn.eo.i.psrto ti sehnacnec fsoarpipotsm(o ulr)dwo +6

azibird utB 8D+C and NK ellsc kill iav rinrfpo!e Why is shti rewnas gor?wn sI it esebacu ti's not eht pyriram efc?etf +2

testready he"T serpmtoeao is het rmjoa eusrco fo rlopteyiotc iictatvy olviednv ni eht eniagnoret fo pdseeitp rof nnapttreeois by joamr ticpimiihootblsayt elmxpoc lscas I e.eluslmoc eW retopr het nwe renaoobtisv atht rombotebzi luoatgeewd-rns HLA aclss I no MM ,scell urisgtnle ni reienascd NK ediltcelame–d yi lss".r.hwtn/l2.we6stg.hi.w//:/mpnciaCn/c7tPp/24cMiomb13lvs +

fatboyslim I tinkh wtha PO iads ioncatdcrst twih hawt t2ch2@-ac tcdie ni eth ebMudP cl.eirta +

an1 PO aisd "Oyln yb respenixso fo eht ,raoetesmop or ist nvooese-rsir,pxe nac tehes naumtt iotpsnre be ddrdgaee atfs oheung to not be aisyeddpl by CMH .I" UW DQI 71146 assy thta a irtoenp oeurdnsge tgaranodide yb eth bquniiitu paoemtesro ap,aywht ratfe hcihw it osge to eth RE nad ehtn is sptnerede ot eht clle cusrefa for MHC 1 respesno nidgael to apptiosos vai mesorrpf adn .yzangrems avgiHn a esoarmpoet nihbiitor udlwo uataycll etpvren eth CMH serepsno cbuease no srnitope ear adyisdlpe. Asol ento htta eth qseiuont says wchih ceposrs lwli eb dete,caff ereht is no tmenoin of einrcesa ro srdaee.ce So se,y the CHM /1 C8D ahpsatyw si feadtec,f ubt i'st lyacualt dwon getdu.arel nA cnaesbe of MHC 1 ldsae to NK clle mdeideat .atdeh +

"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/

+3/- donttrustmyanswers(74)

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submitted by ∗tinydoc(276)

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:5feyH/RUutm/J3zb/thIoth.usp

MAO of moreoeostp irboiishtn ofr MM. RTD:L si htta ehty ablsyliac kblco eth tosoeeormp frmo tnonuficngi os htat emoymla lelsc ca'tn erelcyc orpinste (tehy keam a ont of )hmte adn enwh yhte n'act be erldecyc hyet dilbu pu nad tahst xoitc ot eth cell dan ti dise.

benyod atth hte sountiqe is ayallscib akgisn if eht hniiiibotn fo eptssoomeor sint ciesipfc to eth Myeamlo cslel nda it inbhteidi erhot ce'sll oesmrspeoot thaw lduwo be ?fcetfdee

MHC lscsa I si ernteps no all ecteuadln lcesl l(la leslc in het doby tpxece BC)R dan fnnoituc to peensrt gdensooeun eistanng to C+8D t cslle ot be eyodtedsr or(f amelxep rlVia DNA in na intecfde l.ecl) ehT ywa tehy do shti is by akgtin hte eptroin it nsede to tpserne nad nagibkre it ndow toni cuhm lamersl ptpeied hcsian o(s it cna ift no eht IMC.H If itsh pets aws hiteidinb in otrhe clles ehnt teh the eteanitosrPn fo CMH I tnoldwu eb abel ot tnrpese ihetr nintgeas to D+C8 T leslc dan talaruN krllei ecsll. as the eiqutosn eliips.m

eTh toniquse saw erusp kcrity eusabec fi uyo dn'to okwn woh reospotmoe thirbniiso okrw then oyu ratts kgoonil rfo na waerns htat dluow xinlpae hwo yhet wolud likl ourtm lcsle as llew. I gto it wnorg ot.o It iueeqrdr eenldwgok fo het wya CMH I erpsntes iete.spdp

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submitted by ∗krewfoo99(116)

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Why wdluo psrrfeoin eb eth ogwrn a?rsnwe tuoWndl tnculaamicuo fo ctixo ptniesro eacsu teh lecl ot ernoudg ptoaoipss ?

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ergogenic22 eBobmortiz deos not itdrclye acavtiet ifrnreop. It iectyrld nisibtih eht easpoermto cwihh → enelbas +8CD T lcsel to ianttiei staooipps → avi rrpfeino release (in necssee a ornawstdme tcefe.f) +4

drzed a,xtclyE ti egirsrtg the lclse to orgednu psipotsao hwcih emnas hatt ti can htreei eb elcl midteead fnpeiorr( nda ymagerzn aiv AL/S)SFAF OR ti dlcou asol eb urhoght teh sincntiri ahawpty (.eg. ;inticdlaohmor mcothoecyr )c +

powerhouseofthecell ntueQoi:s utB how do DC8 lselc hvea a eorl in tihs cersspo acxlety ni the ettvi?gen Is it iynsga htat enhw eht insoretp uldib up, yoln ehtn od C8D eclls ecom and asenitd of HCM I tsneignper to m,oseaoertps yteh neestpr it to CD8 ot iienitta t?opoasisp +

flexatronn heeeltcroo@lhfpeuwos os ti lla oegs cabk to aicbs omminu (i tgo ihst gnorw and ptu spitosoap sa ll)ew tbu rtfea ivnrwgeei nvtearle inak drs,ca i wno teg .t oiS toeamspsore erabk ondw edaggt roesnitp iitwnh hte clle dn.e)osgou(ne Teh ednrokawb rsutpocd egt kntae up yb postrantr datoeicssa twih iagtenn segnrsocip AT(P) nad uohrbtg to eht ugroh .RE Teh aebnkrowd sdturocp aer enht doaeld onto MHC I uelomecsl dna thurgob to het asrfcue fo eht ce.ll henW hngitkni tabou CMH I, itnhk tbuao CD8+ T llecs FA( HCM 1 x 8 = 8woNDC. ot arz,immuse wnhe giuns a teasorompe r,iiniboht roy'ue cigbnokl ttah gatgnig adn CMH I loadign osers.cp As esadtt bfeeor, DC8 eircezgsno MCH I h(hcwi 'nwto peapnh henw gunsi seeht ugsr)d +3

whosdaprincesss telnrnxfao@ tnahk uyo !!!! +

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submitted by ∗abhishek021196(120)

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rbiz,Bomoet irbmizfloac

iMnmcesah = astemoPero ,isbrnotiih uncide tersra at -MG2 aphse nad opip.stosa

seU = eptlulMi a,oemlym eamntl clle y.mmapohl

dAv ffecEts = hPerlpriea y,epruoahtn peshre zosret caroinaetvti

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tyrionwill rduen brBte,zomoi the eamsepoort noactn dstgei liarv Ag nda ntprsees it ot eht erdnobbdm-aeenm -.MHCI eeoferrhT T8cCD- nanotc ecgoeirzn teh htos cslle iitonancgn salpreed ZVV. atTh is ayolbpbr hyw niglsesh is one fo eht lrauppo ised eefcft fo orBimtbzoe. +

kcyanide101 heT durg sibihnti etsomeor.po eneHc trhee si no aemrngft baavliale uhgothr TAP endiis C4D llec to ldoa ntou CHM ...I. As hsuc het C8D ieepratotnsn to cellT si .eentvprde eTh anigumtclcau rptnoesi dsenii hte C8D clesl whihc aer ton einbg benokr wodn yb het opeeoortms seuac it to uodnger oopasitps +

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