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NBME 23 Answers

nbme23/Block 1/Question#7 (37.2 difficulty score)
Which of the following is present in integral ...
Transmembrane regionπŸ”
tags: biochem cell_bio 

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submitted by step420(33),
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gIertaln neembmar psioernt era fodnu witnhi teh plsmaa bmraneem nda apsn hte owhle ehnglt r.coass The dneiis fo eht enarbemm is vyre pocdhhiybro eud to the nglo acobnr sciahn. evtinsxEe oocbhpdhyri tieionnacrts ebetwen het ptireno sedi chani nda eht dilpi saitl lwil eplh hoarcn eht reopitn in eth .enbmeram

yb_26  O-linked glycosylation of secreted and membrane bound proteins is a post-translational event that takes place in the cis-Golgi compartment after N-glycosylation and folding of the protein +18  

submitted by irgunner(13),

I was thinking signal sequence on the N-terminal end that would direct the protein into the RER to be then implanted into the plasma membrane. I guess transmembrane region is the better more specific answer?

drdoom  A bilayer has hydrophobic tails (polar head + nonpolar tails). If the N-terminus could be embedded in there, it would also have to be hydrophobic; but if an N-terminus were hydrophobic, it wouldn't dissolve well in the cytosol (=mostly water). In fact, an N-terminus probably wouldn't dissolve at all. If it were hydrophobic, it would aggregate with other, nearby N-terminuses (or other hydrophobic motifs). But if that happened, shuttle proteins couldn't recognize N-terminuses in the first place (they wouldn't be sterically accessible), nor deliver them to the rER. +1  

submitted by yb_26(244),
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ieO-dknl tosaiylnoclgy of tesecedr nad embmaern dnbuo irsptnoe si a nlspratalioonsat-t tnvee tath sketa lacep ni het sciG-ogli ampnreottcm treaf i-yNtgnslclooya dna idfnlog of teh tienrpo